Ultrasensitive label-free tobramycin detection with aptamer-functionalized ZnO TFT biosensor

Abhijeet Barua, Thinh H. Nguyen, Yao Wu, Vishal M. Jain, Ryan J. White, Rashmi Jha

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Aminoglycoside antibiotic such as tobramycin is critical to the treatment of Gram-negative bacterial diseases such as Cystic Fibrosis (Pseudomonas aeruginosa) and other respiratory problems routinely seen in military personnel. Bottom gate (BG) zinc oxide (ZnO) ultra-Thin film transistors (TFTs) were fabricated and functionalized with thiol-Anchored aptamers as sensitive tobramycin biosensors and a Lower Detection Limit (LDL) of 0.1 nM was extracted from the adsorption coverage isotherm. Sputter deposition of (ZnO) allows the control of film thickness, stoichiometry, defects and interface states. Intrinsically high surface morphology of ZnO allows improved aptamer functionalization and sensitivity of detection.

Original languageEnglish (US)
Title of host publicationNAECON 2018 - IEEE National Aerospace and Electronics Conference
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages331-338
Number of pages8
ISBN (Electronic)9781538665572
DOIs
StatePublished - Dec 3 2018
Externally publishedYes
Event2018 IEEE National Aerospace and Electronics Conference, NAECON 2018 - Dayton, United States
Duration: Jul 23 2018Jul 26 2018

Publication series

NameProceedings of the IEEE National Aerospace Electronics Conference, NAECON
Volume2018-July
ISSN (Print)0547-3578
ISSN (Electronic)2379-2027

Conference

Conference2018 IEEE National Aerospace and Electronics Conference, NAECON 2018
Country/TerritoryUnited States
CityDayton
Period7/23/187/26/18

Keywords

  • aptamer
  • biosensor
  • cystic fibrosis
  • functionalization
  • sputter deposition
  • thin film transistor
  • tobramycin
  • ZnO

ASJC Scopus subject areas

  • Computer Networks and Communications
  • Computer Science Applications
  • Control and Systems Engineering
  • Electrical and Electronic Engineering

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