Ultrasensitive label-free tobramycin detection with aptamer-functionalized ZnO TFT biosensor

Abhijeet Barua; Thinh H. Nguyen; Yao Wu; Vishal M. Jain; Ryan J. White; Rashmi Jha

doi:10.1109/NAECON.2018.8556707

Ultrasensitive label-free tobramycin detection with aptamer-functionalized ZnO TFT biosensor

Abhijeet Barua, Thinh H. Nguyen, Yao Wu, Vishal M. Jain, Ryan J. White, Rashmi Jha

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Aminoglycoside antibiotic such as tobramycin is critical to the treatment of Gram-negative bacterial diseases such as Cystic Fibrosis (Pseudomonas aeruginosa) and other respiratory problems routinely seen in military personnel. Bottom gate (BG) zinc oxide (ZnO) ultra-Thin film transistors (TFTs) were fabricated and functionalized with thiol-Anchored aptamers as sensitive tobramycin biosensors and a Lower Detection Limit (LDL) of 0.1 nM was extracted from the adsorption coverage isotherm. Sputter deposition of (ZnO) allows the control of film thickness, stoichiometry, defects and interface states. Intrinsically high surface morphology of ZnO allows improved aptamer functionalization and sensitivity of detection.

Original language	English (US)
Title of host publication	NAECON 2018 - IEEE National Aerospace and Electronics Conference
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	331-338
Number of pages	8
ISBN (Electronic)	9781538665572
DOIs	https://doi.org/10.1109/NAECON.2018.8556707
State	Published - Dec 3 2018
Externally published	Yes
Event	2018 IEEE National Aerospace and Electronics Conference, NAECON 2018 - Dayton, United States Duration: Jul 23 2018 → Jul 26 2018

Publication series

Name	Proceedings of the IEEE National Aerospace Electronics Conference, NAECON
Volume	2018-July
ISSN (Print)	0547-3578
ISSN (Electronic)	2379-2027

Conference

Conference	2018 IEEE National Aerospace and Electronics Conference, NAECON 2018
Country/Territory	United States
City	Dayton
Period	7/23/18 → 7/26/18

Keywords

ZnO
aptamer
biosensor
cystic fibrosis
functionalization
sputter deposition
thin film transistor
tobramycin

ASJC Scopus subject areas

Computer Networks and Communications
Computer Science Applications
Control and Systems Engineering
Electrical and Electronic Engineering

Access to Document

10.1109/NAECON.2018.8556707

Cite this

Barua, A., Nguyen, T. H., Wu, Y., Jain, V. M., White, R. J., & Jha, R. (2018). Ultrasensitive label-free tobramycin detection with aptamer-functionalized ZnO TFT biosensor. In NAECON 2018 - IEEE National Aerospace and Electronics Conference (pp. 331-338). Article 8556707 (Proceedings of the IEEE National Aerospace Electronics Conference, NAECON; Vol. 2018-July). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/NAECON.2018.8556707

Ultrasensitive label-free tobramycin detection with aptamer-functionalized ZnO TFT biosensor. / Barua, Abhijeet; Nguyen, Thinh H.; Wu, Yao et al.
NAECON 2018 - IEEE National Aerospace and Electronics Conference. Institute of Electrical and Electronics Engineers Inc., 2018. p. 331-338 8556707 (Proceedings of the IEEE National Aerospace Electronics Conference, NAECON; Vol. 2018-July).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Barua, A, Nguyen, TH, Wu, Y, Jain, VM, White, RJ & Jha, R 2018, Ultrasensitive label-free tobramycin detection with aptamer-functionalized ZnO TFT biosensor. in NAECON 2018 - IEEE National Aerospace and Electronics Conference., 8556707, Proceedings of the IEEE National Aerospace Electronics Conference, NAECON, vol. 2018-July, Institute of Electrical and Electronics Engineers Inc., pp. 331-338, 2018 IEEE National Aerospace and Electronics Conference, NAECON 2018, Dayton, United States, 7/23/18. https://doi.org/10.1109/NAECON.2018.8556707

Barua A, Nguyen TH, Wu Y, Jain VM, White RJ, Jha R. Ultrasensitive label-free tobramycin detection with aptamer-functionalized ZnO TFT biosensor. In NAECON 2018 - IEEE National Aerospace and Electronics Conference. Institute of Electrical and Electronics Engineers Inc. 2018. p. 331-338. 8556707. (Proceedings of the IEEE National Aerospace Electronics Conference, NAECON). doi: 10.1109/NAECON.2018.8556707

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title = "Ultrasensitive label-free tobramycin detection with aptamer-functionalized ZnO TFT biosensor",

abstract = "Aminoglycoside antibiotic such as tobramycin is critical to the treatment of Gram-negative bacterial diseases such as Cystic Fibrosis (Pseudomonas aeruginosa) and other respiratory problems routinely seen in military personnel. Bottom gate (BG) zinc oxide (ZnO) ultra-Thin film transistors (TFTs) were fabricated and functionalized with thiol-Anchored aptamers as sensitive tobramycin biosensors and a Lower Detection Limit (LDL) of 0.1 nM was extracted from the adsorption coverage isotherm. Sputter deposition of (ZnO) allows the control of film thickness, stoichiometry, defects and interface states. Intrinsically high surface morphology of ZnO allows improved aptamer functionalization and sensitivity of detection.",

keywords = "ZnO, aptamer, biosensor, cystic fibrosis, functionalization, sputter deposition, thin film transistor, tobramycin",

author = "Abhijeet Barua and Nguyen, {Thinh H.} and Yao Wu and Jain, {Vishal M.} and White, {Ryan J.} and Rashmi Jha",

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AU - White, Ryan J.

AU - Jha, Rashmi

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AB - Aminoglycoside antibiotic such as tobramycin is critical to the treatment of Gram-negative bacterial diseases such as Cystic Fibrosis (Pseudomonas aeruginosa) and other respiratory problems routinely seen in military personnel. Bottom gate (BG) zinc oxide (ZnO) ultra-Thin film transistors (TFTs) were fabricated and functionalized with thiol-Anchored aptamers as sensitive tobramycin biosensors and a Lower Detection Limit (LDL) of 0.1 nM was extracted from the adsorption coverage isotherm. Sputter deposition of (ZnO) allows the control of film thickness, stoichiometry, defects and interface states. Intrinsically high surface morphology of ZnO allows improved aptamer functionalization and sensitivity of detection.

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Ultrasensitive label-free tobramycin detection with aptamer-functionalized ZnO TFT biosensor

Abstract

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Conference

Keywords

ASJC Scopus subject areas

Access to Document

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