Ultrasensitive glycogen synthesis in Cyanobacteria

Diego F. Gómez Casati, Miguel A. Aon, Alberto A. Iglesias

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Cyanobacter ADPglucose pyrophosphorylase exhibits a ultrasensitive response in activity towards its allosteric effector 3-phosphoglycerate, elicited by orthophosphate and polyethyleneglycol-induced molecular crowding. The ultrasensitive response was observed either when the enzyme operates in the zero or first order region for its physiological substrates. The ultrasensitivity exhibited maximal amplification factors of 15-19-fold with respect to 1% of the maximal system velocity. Only a 2.4-3.8-fold increase in 3PGA concentration was necessary to augment the flux from 10% to 90% through AGPase as compared with 200-fold required for the control. The results are discussed in terms of finely tuned regulatory mechanisms of polysaccharide synthesis in oxygenic photosynthetic organisms. Copyright (C) 1999 Federation of European Biochemical Societies.

Original languageEnglish (US)
Pages (from-to)117-121
Number of pages5
JournalFEBS Letters
Issue number1
StatePublished - Mar 5 1999
Externally publishedYes


  • ADPglucose pyrophosphorylase
  • Anabaena PCC 7120
  • Enzyme regulation
  • Glycogen and starch biosynthesis
  • Molecular crowding

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology


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