Ultra-thin flexible polyimide neural probe embedded in a dissolvable maltose-coated microneedle

Zhuolin Xiang, Shih Cheng Yen, Ning Xue, Tao Sun, Wei Mong Tsang, Songsong Zhang, Lun De Liao, Nitish V. Thakor, Chengkuo Lee

Research output: Contribution to journalArticlepeer-review

85 Scopus citations


The ultra-thin flexible polyimide neural probe can reduce the glial sheath growth on the probe body while its flexibility can minimize the micromotion between the probe and brain tissue. To provide sufficient stiffness for penetration purposes, we developed a drawing lithography technology for uniform maltose coating to make the maltose-coated polyimide neural probe become a stiff microneedle. The coating thicknesses under different temperature and the corresponding stiffness are studied. It has been proven that the coated maltose is dissolved by body fluids after implantation for a few seconds. Moreover, carbon nanotubes are coated on the neural probe recording electrodes to improve the charge delivery ability and reduce the impedance. Last but not least, the feasibility and recording characteristic of this ultra-thin polyimide neural probe embedded in a maltose-coated microneedle are further demonstrated by in vivo tests.

Original languageEnglish (US)
Article number065015
JournalJournal of Micromechanics and Microengineering
Issue number6
StatePublished - Jun 1 2014


  • dissolvable
  • flexible
  • maltose
  • microneedle
  • neural probe
  • ultra-thin

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Mechanics of Materials
  • Mechanical Engineering
  • Electrical and Electronic Engineering


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