Tyrosine phosphatase SHP-1 in allergic and anaphylactic inflammation

Zhou Zhu; Sun Young Oh; You Sook Cho; Li Zhang; Yoon Keun Kim; Tao Zheng

doi:10.1007/s12026-009-8134-5

Tyrosine phosphatase SHP-1 in allergic and anaphylactic inflammation

Zhou Zhu, Sun Young Oh, You Sook Cho, Li Zhang, Yoon Keun Kim, Tao Zheng

Research output: Contribution to journal › Review article › peer-review

15 Scopus citations

Abstract

Protein tyrosine phosphatase SHP-1 is an essential regulatory molecule in many different signaling pathways. The biological importance of SHP-1 is underscored by the motheaten mutant mouse strains with immunological disorders involving multiple organs and by the close association of aberrant SHP-1 expression with several human diseases. Recent studies provided some compelling evidence that supports a role of SHP-1 in regulating mast cell development and function and also in regulating type 2 allergic inflammatory responses in both innate and adaptive immune responses. In this article, we summarize the recent advancement of our understanding of this interesting phosphatase in the important area of allergic inflammation.

Original language	English (US)
Pages (from-to)	3-13
Number of pages	11
Journal	Immunologic Research
Volume	47
Issue number	1-3
DOIs	https://doi.org/10.1007/s12026-009-8134-5
State	Published - Jul 2010
Externally published	Yes

Keywords

Allergic inflammatory response
Allergy
Asthma
Mast cells
Phosphatase
Th2 cytokines

ASJC Scopus subject areas

Immunology

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10.1007/s12026-009-8134-5

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title = "Tyrosine phosphatase SHP-1 in allergic and anaphylactic inflammation",

abstract = "Protein tyrosine phosphatase SHP-1 is an essential regulatory molecule in many different signaling pathways. The biological importance of SHP-1 is underscored by the motheaten mutant mouse strains with immunological disorders involving multiple organs and by the close association of aberrant SHP-1 expression with several human diseases. Recent studies provided some compelling evidence that supports a role of SHP-1 in regulating mast cell development and function and also in regulating type 2 allergic inflammatory responses in both innate and adaptive immune responses. In this article, we summarize the recent advancement of our understanding of this interesting phosphatase in the important area of allergic inflammation.",

keywords = "Allergic inflammatory response, Allergy, Asthma, Mast cells, Phosphatase, Th2 cytokines",

author = "Zhou Zhu and Oh, {Sun Young} and Cho, {You Sook} and Li Zhang and Kim, {Yoon Keun} and Tao Zheng",

note = "Funding Information: Acknowledgments This work was supported by the NIH grants HL079349 to ZZ and AI075025 to TZ and a grant from the China Scholarship Council to LZ. We thank Phyllis Zhu for proofreading the manuscript.",

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doi = "10.1007/s12026-009-8134-5",

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AU - Zhu, Zhou

AU - Oh, Sun Young

AU - Cho, You Sook

AU - Zhang, Li

AU - Kim, Yoon Keun

AU - Zheng, Tao

N1 - Funding Information: Acknowledgments This work was supported by the NIH grants HL079349 to ZZ and AI075025 to TZ and a grant from the China Scholarship Council to LZ. We thank Phyllis Zhu for proofreading the manuscript.

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N2 - Protein tyrosine phosphatase SHP-1 is an essential regulatory molecule in many different signaling pathways. The biological importance of SHP-1 is underscored by the motheaten mutant mouse strains with immunological disorders involving multiple organs and by the close association of aberrant SHP-1 expression with several human diseases. Recent studies provided some compelling evidence that supports a role of SHP-1 in regulating mast cell development and function and also in regulating type 2 allergic inflammatory responses in both innate and adaptive immune responses. In this article, we summarize the recent advancement of our understanding of this interesting phosphatase in the important area of allergic inflammation.

AB - Protein tyrosine phosphatase SHP-1 is an essential regulatory molecule in many different signaling pathways. The biological importance of SHP-1 is underscored by the motheaten mutant mouse strains with immunological disorders involving multiple organs and by the close association of aberrant SHP-1 expression with several human diseases. Recent studies provided some compelling evidence that supports a role of SHP-1 in regulating mast cell development and function and also in regulating type 2 allergic inflammatory responses in both innate and adaptive immune responses. In this article, we summarize the recent advancement of our understanding of this interesting phosphatase in the important area of allergic inflammation.

KW - Allergic inflammatory response

KW - Allergy

KW - Asthma

KW - Mast cells

KW - Phosphatase

KW - Th2 cytokines

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Tyrosine phosphatase SHP-1 in allergic and anaphylactic inflammation

Abstract

Keywords

ASJC Scopus subject areas

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