Tyrosine Kinase Inhibitor Use and Wound Healing in Tracheoesophageal Punctures

Christopher Britt, Jonathon O. Russell

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Tyrosine kinase inhibitors (TKIs) aid in prolonging life in patients with advanced locoregional thyroid malignancy. Such patients may undergo total laryngectomy for local disease control and tracheoesophageal puncture (TEP) for speech rehabilitation. Enlargement of TEP fistulas is usually attributed to wound healing issues and leads to major complications. Four laryngectomies with TEP were performed between 2015 and 2016 and subsequently placed on a TKI. Three patients developed a complication after TKI treatment, and 2 patients had a tracheoesophageal fistula. Patients should be counseled about possible wound healing risks associated with TKIs.

Original languageEnglish (US)
Pages (from-to)510-512
Number of pages3
JournalEar, Nose and Throat Journal
Issue number8
StatePublished - Sep 1 2019


  • TEP
  • TKI
  • biologics
  • laryngectomy
  • prosthesis
  • thyroid cancer
  • thyroid carcinoma
  • thyroidectomy
  • tracheoesophageal fistula
  • tyrosine kinase inhibitor
  • wound healing

ASJC Scopus subject areas

  • Otorhinolaryngology


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