Tyrosine-hydroxylase-containing neurons in the primate basal forebrain magnocellular complex

Gunnar K. Gouras, Naomi E. Rance, W. Scott Young, Vassilis E. Koliatsos

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Immunocytochemistry and in situ hybridization for tyrosine hydroxylase (TH) were used to study the distribution of putative catecholaminergic neurons in the basal forebrain magnocellular complex (BFMC) of monkeys and humans. Magnocellular TH-expressing neurons in the primate BFMC are distributed along a rostrocaudal gradient, with the largest proportion of these cells located in the medial septal nucleus and nucleus of the diagonal band of Broca; smaller TH-containing neurons generally follow the same distribution. These findings suggest that, within rostromedial segments of the BFMC, there is a distinct subpopulation of neurons that express catecholamine-synthesizing enzymes. Further research is necessary to establish whether these neurons utilize one or more catecholamines as neurotransmitters.

Original languageEnglish (US)
Pages (from-to)287-293
Number of pages7
JournalBrain research
Issue number1-2
StatePublished - Jul 3 1992


  • Catecholaminergic
  • Diagonal band
  • Human
  • Monkey
  • Nucleus basalis
  • Septum

ASJC Scopus subject areas

  • General Neuroscience
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology


Dive into the research topics of 'Tyrosine-hydroxylase-containing neurons in the primate basal forebrain magnocellular complex'. Together they form a unique fingerprint.

Cite this