Type-restricted neutralization of molecular clones of human immunodeficiency virus

David J. Looney; Amanda G. Fisher; Scott D. Putney; James R. Rusche; Robert R. Redfield; Donald S. Burke; Robert C. Gallo; F. Wong-Staal

doi:10.1126/science.3388046

Type-restricted neutralization of molecular clones of human immunodeficiency virus

David J. Looney, Amanda G. Fisher, Scott D. Putney, James R. Rusche, Robert R. Redfield, Donald S. Burke, Robert C. Gallo, F. Wong-Staal

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

88 Scopus citations

Abstract

In a study of the immunologic significance of the genetic diversity present within single isolates of human immunodeficiency virus type 1 (HIV-1), the neutralization of viruses derived from molecular clones of the HIV-1 strain HTLV-III_B by an extensive panel of sera was compared. Sera from HIV-1-infected patients and from goats immunized with polyacrylamide gel-purified HIV-1 envelope glycoprotein (gp120), native gp120, or gp120-derived recombinant peptides, showed marked heterogeneity in neutralizing activity against these closely related viruses. The change of a single amino acid residue in gp120 may account for such "clonal restriction" of neutralizing activity.

Original language	English (US)
Pages (from-to)	357-359
Number of pages	3
Journal	Science
Volume	241
Issue number	4863
DOIs	https://doi.org/10.1126/science.3388046
State	Published - Jan 1 1988

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abstract = "In a study of the immunologic significance of the genetic diversity present within single isolates of human immunodeficiency virus type 1 (HIV-1), the neutralization of viruses derived from molecular clones of the HIV-1 strain HTLV-IIIB by an extensive panel of sera was compared. Sera from HIV-1-infected patients and from goats immunized with polyacrylamide gel-purified HIV-1 envelope glycoprotein (gp120), native gp120, or gp120-derived recombinant peptides, showed marked heterogeneity in neutralizing activity against these closely related viruses. The change of a single amino acid residue in gp120 may account for such {"}clonal restriction{"} of neutralizing activity.",

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AU - Looney, David J.

AU - Fisher, Amanda G.

AU - Putney, Scott D.

AU - Rusche, James R.

AU - Redfield, Robert R.

AU - Burke, Donald S.

AU - Gallo, Robert C.

AU - Wong-Staal, F.

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Type-restricted neutralization of molecular clones of human immunodeficiency virus

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