Type II DNA topoisomerases

James M. Berger

doi:10.1016/S0959-440X(98)80006-7

Type II DNA topoisomerases

James M. Berger

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Abstract

Type II DNA topoisomerases are enzymes capable of passing one DNA duplex through another. A combination of structural and biochemical analyses is illuminating the mechanistic details of this transport reaction, revealing the sites of DNA and nucleotide binding and the existence of large-scale domain motions.

Original language	English (US)
Pages (from-to)	26-32
Number of pages	7
Journal	Current Opinion in Structural Biology
Volume	8
Issue number	1
DOIs	https://doi.org/10.1016/S0959-440X(98)80006-7
State	Published - Feb 1998
Externally published	Yes

ASJC Scopus subject areas

Structural Biology
Molecular Biology

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10.1016/S0959-440X(98)80006-7

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title = "Type II DNA topoisomerases",

abstract = "Type II DNA topoisomerases are enzymes capable of passing one DNA duplex through another. A combination of structural and biochemical analyses is illuminating the mechanistic details of this transport reaction, revealing the sites of DNA and nucleotide binding and the existence of large-scale domain motions.",

author = "Berger, {James M.}",

note = "Funding Information: The author would like to thank DB Wigley for the GyrB ATPase coordinates, and A Maxwell and R Liddington for the GyrAs9 coordinates. The author would also like to thank D Fass, JE Lindsley and AS Lynch for critical reading ofc:his manuscript and their comments. The WM Keck Foundation and the 'Whitehead Institute have generously provided JMB with funding and support for this work.",

year = "1998",

month = feb,

doi = "10.1016/S0959-440X(98)80006-7",

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AU - Berger, James M.

N1 - Funding Information: The author would like to thank DB Wigley for the GyrB ATPase coordinates, and A Maxwell and R Liddington for the GyrAs9 coordinates. The author would also like to thank D Fass, JE Lindsley and AS Lynch for critical reading ofc:his manuscript and their comments. The WM Keck Foundation and the 'Whitehead Institute have generously provided JMB with funding and support for this work.

PY - 1998/2

Y1 - 1998/2

N2 - Type II DNA topoisomerases are enzymes capable of passing one DNA duplex through another. A combination of structural and biochemical analyses is illuminating the mechanistic details of this transport reaction, revealing the sites of DNA and nucleotide binding and the existence of large-scale domain motions.

AB - Type II DNA topoisomerases are enzymes capable of passing one DNA duplex through another. A combination of structural and biochemical analyses is illuminating the mechanistic details of this transport reaction, revealing the sites of DNA and nucleotide binding and the existence of large-scale domain motions.

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Type II DNA topoisomerases

Abstract

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