Type I diabetes in an adolescent with common variable immunodeficiency

John E. Moffitt, Margaret F. Guill, Mary Sue Leffell, Edwin W. Ades, C. Lynne Burek, Steven A. Lobel, William H. Hoffman

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


A male adolescent with common variable immunodeficiency developed type I diabetes approximately 1 year after the initiation of immunoglobulin therapy. Immunologic evaluation revealed decreased numbers of T cells and an intrinsic B cell defect in immunoglobulin production. Lymphocytes from the patient failed to generate normal suppressor activity. There were no insulin or islet cell antibodies present in the patient's serum or in the commercial immunoglobulin preparations he received. The panent's HLA phenotype included HLA-DR3 and 4, placing him genetically at high risk for type I diabetes.

Original languageEnglish (US)
Pages (from-to)191-196
Number of pages6
JournalThe Journal of allergy and clinical immunology
Issue number2
StatePublished - Aug 1989

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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