Type 1 diabetes pathogenesis: lessons learned and remaining questions

Adebola M. Giwa; Angela Yang; Neha Majety; Kusuma Ananth; Rizwan Ahmed; Mohanraj Sadasivam; Marjan Behzadirad; Zahra Omidian; Tiffany Jackson; Thomas Donner; Abdel R.A. Hamad

doi:10.1016/B978-0-323-91707-0.00003-6

Type 1 diabetes pathogenesis: lessons learned and remaining questions

Adebola M. Giwa, Angela Yang, Neha Majety, Kusuma Ananth, Rizwan Ahmed, Mohanraj Sadasivam, Marjan Behzadirad, Zahra Omidian, Tiffany Jackson, Thomas Donner, Abdel R.A. Hamad

School of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Since the discovery of insulin in the 1920s, significant progress has been made in understanding the pathogenesis of type 1 diabetes and developing sophisticated approaches to manage glucose homeostasis in patients. Key aspects of the disease pathogenesis, however, remain poorly understood, hindering the efforts to find a cure and prophylaxis for this debilitating condition. These efforts are further complicated by gaps in understanding the risk factors and difficulties in early detection. In this chapter, we will highlight the major outstanding questions regarding disease pathogenesis and dwell on lessons learned and the promise of finding solutions in the near future.

Original language	English (US)
Title of host publication	Insulin
Subtitle of host publication	Deficiency, Excess and Resistance in Human Disease
Publisher	Elsevier
Pages	87-106
Number of pages	20
ISBN (Electronic)	9780323917070
ISBN (Print)	9780323985697
DOIs	https://doi.org/10.1016/B978-0-323-91707-0.00003-6
State	Published - Jan 1 2024

Keywords

autoimmunity
epidemiology
immunotherapy
insulin
insulitis
Type 1 diabetes
viral mimicry
β-cell

ASJC Scopus subject areas

General Medicine

Access to Document

10.1016/B978-0-323-91707-0.00003-6

Cite this

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abstract = "Since the discovery of insulin in the 1920s, significant progress has been made in understanding the pathogenesis of type 1 diabetes and developing sophisticated approaches to manage glucose homeostasis in patients. Key aspects of the disease pathogenesis, however, remain poorly understood, hindering the efforts to find a cure and prophylaxis for this debilitating condition. These efforts are further complicated by gaps in understanding the risk factors and difficulties in early detection. In this chapter, we will highlight the major outstanding questions regarding disease pathogenesis and dwell on lessons learned and the promise of finding solutions in the near future.",

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AU - Majety, Neha

AU - Ananth, Kusuma

AU - Ahmed, Rizwan

AU - Sadasivam, Mohanraj

AU - Behzadirad, Marjan

AU - Omidian, Zahra

AU - Jackson, Tiffany

AU - Donner, Thomas

AU - Hamad, Abdel R.A.

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KW - epidemiology

KW - immunotherapy

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KW - insulitis

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Type 1 diabetes pathogenesis: lessons learned and remaining questions

Abstract

Keywords

ASJC Scopus subject areas

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