TY - JOUR
T1 - Two rat homologs of clathrin-associated adaptor proteins
AU - Pevsner, Jonathan
AU - Volknandt, Walter
AU - Wong, Brian R.
AU - Scheller, Richard H.
N1 - Funding Information:
We thank Dr. Tomas Kirchhausenf or sharingu npub-lishedd ataa nd N. Varg for manuscrippt reparationT. his work is supportedb y the National Institute of Mental Health.
PY - 1994/9/2
Y1 - 1994/9/2
N2 - A cDNA clone predicted to encode a 46 757-Da protein was isolated from a library derived from the electric lobe of the ray Discopyge ommata. Two rat homologs, p47A and p47B, were subsequently isolated. These three proteins share approx. 80% amino acid (aa) identity to each other and have 27-30% aa identity to rat AP50 and mouse AP47, the medium-chain subunits of adaptor complexes associated with clathrin-coated vesicles. These complexes are involved in receptor-mediated pathways of intracellular transport. Rat p47A mRNA is expressed in all tissues examined, including brain, heart, kidney, liver, lung, muscle and spinal cord. Rat p47B mRNA is detected exclusively in brain and spinal cord, and may participate in nervous system-specific functions such as biogenesis or recycling of synaptic vesicles.
AB - A cDNA clone predicted to encode a 46 757-Da protein was isolated from a library derived from the electric lobe of the ray Discopyge ommata. Two rat homologs, p47A and p47B, were subsequently isolated. These three proteins share approx. 80% amino acid (aa) identity to each other and have 27-30% aa identity to rat AP50 and mouse AP47, the medium-chain subunits of adaptor complexes associated with clathrin-coated vesicles. These complexes are involved in receptor-mediated pathways of intracellular transport. Rat p47A mRNA is expressed in all tissues examined, including brain, heart, kidney, liver, lung, muscle and spinal cord. Rat p47B mRNA is detected exclusively in brain and spinal cord, and may participate in nervous system-specific functions such as biogenesis or recycling of synaptic vesicles.
KW - Assembly proteins
KW - membrane trafficking
KW - ray electric lobe
KW - recycling
KW - vesicles
UR - http://www.scopus.com/inward/record.url?scp=0027981251&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027981251&partnerID=8YFLogxK
U2 - 10.1016/0378-1119(94)90306-9
DO - 10.1016/0378-1119(94)90306-9
M3 - Article
C2 - 8076832
AN - SCOPUS:0027981251
SN - 0378-1119
VL - 146
SP - 279
EP - 283
JO - Gene
JF - Gene
IS - 2
ER -