TY - JOUR
T1 - Two patients with hailey-hailey disease, multiple primary melanomas, and other cancers
AU - Mohr, Melinda R.
AU - Erdag, Gulsun
AU - Shada, Amber L.
AU - Williams, Michael E.
AU - Slingluff, Craig L.
AU - Patterson, James W.
PY - 2011/2
Y1 - 2011/2
N2 - Background: Hailey-Hailey Disease (HHD) is an autosomal dominant skin disorder that is characterized by erythematous and sometimes vesicular, weeping plaques of intertriginous regions. Squamous cell carcinoma and basal cell carcinoma arising in lesions of HHD have been described in the literature. To our knowledge, there are no reports of melanoma or noncutaneous malignant neoplasms associated with HHD. Observations: We discuss the mechanisms of oncogenicity, including genetic, environmental, and iatrogenic factors, in 2 patients with HHD, multiple primary melanomas, and other cancers. Patient 1 had a mucoepidermoid carcinoma of the parotid gland. Patient 2 had a history of acute monoblastic leukemia and malignant peripheral nerve sheath tumor as well as radiologic evidence of an acoustic neurilemmoma. Conclusions: The cause of the cancers in these 2 patients is likely multifactorial. We describe the patients to draw attention to the possible association between HHD and cancer. Additional research should be performed to determine whether patients with HHD have an increased incidence of cancer.
AB - Background: Hailey-Hailey Disease (HHD) is an autosomal dominant skin disorder that is characterized by erythematous and sometimes vesicular, weeping plaques of intertriginous regions. Squamous cell carcinoma and basal cell carcinoma arising in lesions of HHD have been described in the literature. To our knowledge, there are no reports of melanoma or noncutaneous malignant neoplasms associated with HHD. Observations: We discuss the mechanisms of oncogenicity, including genetic, environmental, and iatrogenic factors, in 2 patients with HHD, multiple primary melanomas, and other cancers. Patient 1 had a mucoepidermoid carcinoma of the parotid gland. Patient 2 had a history of acute monoblastic leukemia and malignant peripheral nerve sheath tumor as well as radiologic evidence of an acoustic neurilemmoma. Conclusions: The cause of the cancers in these 2 patients is likely multifactorial. We describe the patients to draw attention to the possible association between HHD and cancer. Additional research should be performed to determine whether patients with HHD have an increased incidence of cancer.
UR - http://www.scopus.com/inward/record.url?scp=79951966697&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79951966697&partnerID=8YFLogxK
U2 - 10.1001/archdermatol.2010.445
DO - 10.1001/archdermatol.2010.445
M3 - Article
C2 - 21339448
AN - SCOPUS:79951966697
SN - 0003-987X
VL - 147
SP - 211
EP - 215
JO - Archives of Dermatology
JF - Archives of Dermatology
IS - 2
ER -