Two Acute Liver Injuries in a Patient With Malnutrition

Amanda Su; Monica Choe; Jacqueline E. Birkness; Berkeley Limketkai; Po Hung Chen

doi:10.14740/jmc3713

Two Acute Liver Injuries in a Patient With Malnutrition

Amanda Su, Monica Choe, Jacqueline E. Birkness, Berkeley Limketkai, Po Hung Chen

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Chronic starvation and refeeding have been associated with liver injury (LI). We present a patient with anorexia nervosa who exhibited both phenomena of malnutrition-related LI. At presentation, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were elevated at 154 and 136 U/L, respectively, and rose rapidly to peaks of 750 and 638 U/L, respectively, as nutrition was introduced. Mechanisms of starvation-related LI include impaired degradation and secretion of lipids, as well as starvation-induced autophagy. LI during refeeding may be related to rapid increase in glucose availability. These phenomena are crucial to consider in patients with chronic starvation undergoing refeeding.

Original language	English (US)
Pages (from-to)	315-318
Number of pages	4
Journal	Journal of Medical Cases
Volume	12
Issue number	8
DOIs	https://doi.org/10.14740/jmc3713
State	Published - 2021

Keywords

Hepatic steatosis
Liver injury
Malnutrition
Refeeding

ASJC Scopus subject areas

General Medicine

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10.14740/jmc3713

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title = "Two Acute Liver Injuries in a Patient With Malnutrition",

abstract = "Chronic starvation and refeeding have been associated with liver injury (LI). We present a patient with anorexia nervosa who exhibited both phenomena of malnutrition-related LI. At presentation, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were elevated at 154 and 136 U/L, respectively, and rose rapidly to peaks of 750 and 638 U/L, respectively, as nutrition was introduced. Mechanisms of starvation-related LI include impaired degradation and secretion of lipids, as well as starvation-induced autophagy. LI during refeeding may be related to rapid increase in glucose availability. These phenomena are crucial to consider in patients with chronic starvation undergoing refeeding.",

keywords = "Hepatic steatosis, Liver injury, Malnutrition, Refeeding",

author = "Amanda Su and Monica Choe and Birkness, {Jacqueline E.} and Berkeley Limketkai and Chen, {Po Hung}",

note = "Funding Information: We gratefully acknowledge funding by the National Institute on Alcohol Abuse and Alcoholism of the National Institutes of Health under award number K23AA028297 (PC) and Gilead Sciences Research Scholars Program in Liver Disease - The Americas (PC). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health or other sponsors. Publisher Copyright: {\textcopyright} The authors",

year = "2021",

doi = "10.14740/jmc3713",

language = "English (US)",

volume = "12",

pages = "315--318",

journal = "Journal of Medical Cases",

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TY - JOUR

T1 - Two Acute Liver Injuries in a Patient With Malnutrition

AU - Su, Amanda

AU - Choe, Monica

AU - Birkness, Jacqueline E.

AU - Limketkai, Berkeley

AU - Chen, Po Hung

N1 - Funding Information: We gratefully acknowledge funding by the National Institute on Alcohol Abuse and Alcoholism of the National Institutes of Health under award number K23AA028297 (PC) and Gilead Sciences Research Scholars Program in Liver Disease - The Americas (PC). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health or other sponsors. Publisher Copyright: © The authors

PY - 2021

Y1 - 2021

N2 - Chronic starvation and refeeding have been associated with liver injury (LI). We present a patient with anorexia nervosa who exhibited both phenomena of malnutrition-related LI. At presentation, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were elevated at 154 and 136 U/L, respectively, and rose rapidly to peaks of 750 and 638 U/L, respectively, as nutrition was introduced. Mechanisms of starvation-related LI include impaired degradation and secretion of lipids, as well as starvation-induced autophagy. LI during refeeding may be related to rapid increase in glucose availability. These phenomena are crucial to consider in patients with chronic starvation undergoing refeeding.

AB - Chronic starvation and refeeding have been associated with liver injury (LI). We present a patient with anorexia nervosa who exhibited both phenomena of malnutrition-related LI. At presentation, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were elevated at 154 and 136 U/L, respectively, and rose rapidly to peaks of 750 and 638 U/L, respectively, as nutrition was introduced. Mechanisms of starvation-related LI include impaired degradation and secretion of lipids, as well as starvation-induced autophagy. LI during refeeding may be related to rapid increase in glucose availability. These phenomena are crucial to consider in patients with chronic starvation undergoing refeeding.

KW - Hepatic steatosis

KW - Liver injury

KW - Malnutrition

KW - Refeeding

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DO - 10.14740/jmc3713

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EP - 318

JO - Journal of Medical Cases

JF - Journal of Medical Cases

IS - 8

ER -

Two Acute Liver Injuries in a Patient With Malnutrition

Abstract

Keywords

ASJC Scopus subject areas

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