Abstract
Transcription and DNA supercoiling are involved in a complex, dynamical and non-linear coupling that results from the basal interaction between DNA and RNA polymerase. We present the first software to simulate this coupling, applicable to a wide range of bacterial organisms. TwisTranscripT allows quantifying its contribution in global transcriptional regulation, and provides a mechanistic basis for the widely observed, evolutionarily conserved and currently unexplained co-regulation of adjacent operons that might play an important role in genome evolution.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 3899-3901 |
| Number of pages | 3 |
| Journal | Bioinformatics |
| Volume | 36 |
| Issue number | 12 |
| DOIs | |
| State | Published - Mar 31 2020 |
| Externally published | Yes |
ASJC Scopus subject areas
- Statistics and Probability
- Biochemistry
- Molecular Biology
- Computer Science Applications
- Computational Theory and Mathematics
- Computational Mathematics
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