Tumors line up for a letdown

Joshua T. Mendell

Research output: Contribution to journalShort surveypeer-review

9 Scopus citations


MicroRNAs (miRNAs) and the pathways that regulate their expression have critical functions during normal development. A new study demonstrates that select cancer cells have appropriated one developmental mechanism of miRNA regulation, the inhibition of let-7 biogenesis by the Lin-28 and Lin-28B RNA binding proteins, to rid themselves of an antitumorigenic miRNA.

Original languageEnglish (US)
Pages (from-to)768-769
Number of pages2
JournalNature genetics
Issue number7
StatePublished - Jul 2009

ASJC Scopus subject areas

  • Genetics


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