Tuberculosis Infection in Pregnant People: Current Practices and Research Priorities

Jyoti S. Mathad, Sharan Yadav, Arthi Vaidyanathan, Amita Gupta, Sylvia M. LaCourse

Research output: Contribution to journalReview articlepeer-review


Women are significantly more likely to develop tuberculosis (TB) disease within the first 90 days after pregnancy than any other time in their lives. Whether pregnancy increases risk of progression from TB infection (TBI) to TB disease is unknown and is an active area of investigation. In this review, we discuss the epidemiology of TB and TBI in pregnancy, TBI diagnostics, and prevalence in pregnancy. We also review TBI treatment and highlight research priorities, such as short-course TB prevention regimens, drug-resistant TB prevention, and additional considerations for safety, tolerability, and pharmacokinetics that are unique to pregnant and postpartum people.

Original languageEnglish (US)
Article number1481
Issue number12
StatePublished - Dec 2022


  • HIV
  • isoniazid
  • postpartum
  • pregnant
  • prevention
  • tuberculosis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Molecular Biology
  • General Immunology and Microbiology
  • Microbiology (medical)
  • Infectious Diseases


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