Tuberculosis Infection in Pregnant People: Current Practices and Research Priorities

Jyoti S. Mathad; Sharan Yadav; Arthi Vaidyanathan; Amita Gupta; Sylvia M. LaCourse

doi:10.3390/pathogens11121481

Tuberculosis Infection in Pregnant People: Current Practices and Research Priorities

Jyoti S. Mathad, Sharan Yadav, Arthi Vaidyanathan, Amita Gupta, Sylvia M. LaCourse

School of Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

Women are significantly more likely to develop tuberculosis (TB) disease within the first 90 days after pregnancy than any other time in their lives. Whether pregnancy increases risk of progression from TB infection (TBI) to TB disease is unknown and is an active area of investigation. In this review, we discuss the epidemiology of TB and TBI in pregnancy, TBI diagnostics, and prevalence in pregnancy. We also review TBI treatment and highlight research priorities, such as short-course TB prevention regimens, drug-resistant TB prevention, and additional considerations for safety, tolerability, and pharmacokinetics that are unique to pregnant and postpartum people.

Original language	English (US)
Article number	1481
Journal	Pathogens
Volume	11
Issue number	12
DOIs	https://doi.org/10.3390/pathogens11121481
State	Published - Dec 2022

Keywords

HIV
isoniazid
postpartum
pregnant
prevention
tuberculosis

ASJC Scopus subject areas

Immunology and Allergy
Molecular Biology
General Immunology and Microbiology
Microbiology (medical)
Infectious Diseases

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10.3390/pathogens11121481

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title = "Tuberculosis Infection in Pregnant People: Current Practices and Research Priorities",

abstract = "Women are significantly more likely to develop tuberculosis (TB) disease within the first 90 days after pregnancy than any other time in their lives. Whether pregnancy increases risk of progression from TB infection (TBI) to TB disease is unknown and is an active area of investigation. In this review, we discuss the epidemiology of TB and TBI in pregnancy, TBI diagnostics, and prevalence in pregnancy. We also review TBI treatment and highlight research priorities, such as short-course TB prevention regimens, drug-resistant TB prevention, and additional considerations for safety, tolerability, and pharmacokinetics that are unique to pregnant and postpartum people.",

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AU - Mathad, Jyoti S.

AU - Yadav, Sharan

AU - Vaidyanathan, Arthi

AU - Gupta, Amita

AU - LaCourse, Sylvia M.

PY - 2022/12

Y1 - 2022/12

N2 - Women are significantly more likely to develop tuberculosis (TB) disease within the first 90 days after pregnancy than any other time in their lives. Whether pregnancy increases risk of progression from TB infection (TBI) to TB disease is unknown and is an active area of investigation. In this review, we discuss the epidemiology of TB and TBI in pregnancy, TBI diagnostics, and prevalence in pregnancy. We also review TBI treatment and highlight research priorities, such as short-course TB prevention regimens, drug-resistant TB prevention, and additional considerations for safety, tolerability, and pharmacokinetics that are unique to pregnant and postpartum people.

AB - Women are significantly more likely to develop tuberculosis (TB) disease within the first 90 days after pregnancy than any other time in their lives. Whether pregnancy increases risk of progression from TB infection (TBI) to TB disease is unknown and is an active area of investigation. In this review, we discuss the epidemiology of TB and TBI in pregnancy, TBI diagnostics, and prevalence in pregnancy. We also review TBI treatment and highlight research priorities, such as short-course TB prevention regimens, drug-resistant TB prevention, and additional considerations for safety, tolerability, and pharmacokinetics that are unique to pregnant and postpartum people.

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KW - isoniazid

KW - postpartum

KW - pregnant

KW - prevention

KW - tuberculosis

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Tuberculosis Infection in Pregnant People: Current Practices and Research Priorities

Abstract

Keywords

ASJC Scopus subject areas

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