Tuberculin skin test reactivity among adults infected with human immunodeficiency virus

Michael P. Johnson; Jacqueline S. Coberly; H. Camile Clermont; Richard E. Chaisson; Homer L. Davis; Phyllis Losikoff; Andrea J. Ruff; Reginald Boulos; Neal A. Halsey

doi:10.1093/infdis/166.1.194

Tuberculin skin test reactivity among adults infected with human immunodeficiency virus

Michael P. Johnson, Jacqueline S. Coberly, H. Camile Clermont, Richard E. Chaisson, Homer L. Davis, Phyllis Losikoff, Andrea J. Ruff, Reginald Boulos, Neal A. Halsey

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Abstract

Infection with the human immunodeficiency virus type 1 (HIV-1) results in decreased cell-mediated immunity, which includes decreased delayed hypersensitivity to skin test antigens. HIV-1 seropositivity and skin test reactivity to purified protein derivative (PPD) were determined among 2042 healthy Haitian adults with normal chest radiographs. Among HIV-1-seropositive individuals, 52.3% (146/279) had PPD reactions ⋟10 mm compared with 67.2% (1184/1763) of the seronegative adults (P <.001). However, the percentage of HIV-1-seropositive individuals with PPD reactions ⋟5 mm was similar to the percentage of seronegative adults with PPD reactions ⋟10 mm (180/279 [64.5%] vs. 1184/1763 [67.2%]). Assuming that the rate of prior infection with Mycobacterium tuberculosis was similar for HIV-1-seronegative and -seropositive populations, these data provide support for the recent recommendations to use induration of >5 mm as evidence of past infection with M. tuberculosis in HIV-1 seropositive adults.

Original language	English (US)
Pages (from-to)	194-208
Number of pages	15
Journal	Journal of Infectious Diseases
Volume	166
Issue number	1
DOIs	https://doi.org/10.1093/infdis/166.1.194
State	Published - Jul 1992

ASJC Scopus subject areas

Immunology and Allergy
Infectious Diseases

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10.1093/infdis/166.1.194

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title = "Tuberculin skin test reactivity among adults infected with human immunodeficiency virus",

abstract = "Infection with the human immunodeficiency virus type 1 (HIV-1) results in decreased cell-mediated immunity, which includes decreased delayed hypersensitivity to skin test antigens. HIV-1 seropositivity and skin test reactivity to purified protein derivative (PPD) were determined among 2042 healthy Haitian adults with normal chest radiographs. Among HIV-1-seropositive individuals, 52.3% (146/279) had PPD reactions ⋟10 mm compared with 67.2% (1184/1763) of the seronegative adults (P <.001). However, the percentage of HIV-1-seropositive individuals with PPD reactions ⋟5 mm was similar to the percentage of seronegative adults with PPD reactions ⋟10 mm (180/279 [64.5%] vs. 1184/1763 [67.2%]). Assuming that the rate of prior infection with Mycobacterium tuberculosis was similar for HIV-1-seronegative and -seropositive populations, these data provide support for the recent recommendations to use induration of >5 mm as evidence of past infection with M. tuberculosis in HIV-1 seropositive adults.",

author = "Johnson, {Michael P.} and Coberly, {Jacqueline S.} and {Camile Clermont}, H. and Chaisson, {Richard E.} and Davis, {Homer L.} and Phyllis Losikoff and Ruff, {Andrea J.} and Reginald Boulos and Halsey, {Neal A.}",

year = "1992",

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doi = "10.1093/infdis/166.1.194",

language = "English (US)",

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AU - Johnson, Michael P.

AU - Coberly, Jacqueline S.

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AU - Chaisson, Richard E.

AU - Davis, Homer L.

AU - Losikoff, Phyllis

AU - Ruff, Andrea J.

AU - Boulos, Reginald

AU - Halsey, Neal A.

PY - 1992/7

Y1 - 1992/7

N2 - Infection with the human immunodeficiency virus type 1 (HIV-1) results in decreased cell-mediated immunity, which includes decreased delayed hypersensitivity to skin test antigens. HIV-1 seropositivity and skin test reactivity to purified protein derivative (PPD) were determined among 2042 healthy Haitian adults with normal chest radiographs. Among HIV-1-seropositive individuals, 52.3% (146/279) had PPD reactions ⋟10 mm compared with 67.2% (1184/1763) of the seronegative adults (P <.001). However, the percentage of HIV-1-seropositive individuals with PPD reactions ⋟5 mm was similar to the percentage of seronegative adults with PPD reactions ⋟10 mm (180/279 [64.5%] vs. 1184/1763 [67.2%]). Assuming that the rate of prior infection with Mycobacterium tuberculosis was similar for HIV-1-seronegative and -seropositive populations, these data provide support for the recent recommendations to use induration of >5 mm as evidence of past infection with M. tuberculosis in HIV-1 seropositive adults.

AB - Infection with the human immunodeficiency virus type 1 (HIV-1) results in decreased cell-mediated immunity, which includes decreased delayed hypersensitivity to skin test antigens. HIV-1 seropositivity and skin test reactivity to purified protein derivative (PPD) were determined among 2042 healthy Haitian adults with normal chest radiographs. Among HIV-1-seropositive individuals, 52.3% (146/279) had PPD reactions ⋟10 mm compared with 67.2% (1184/1763) of the seronegative adults (P <.001). However, the percentage of HIV-1-seropositive individuals with PPD reactions ⋟5 mm was similar to the percentage of seronegative adults with PPD reactions ⋟10 mm (180/279 [64.5%] vs. 1184/1763 [67.2%]). Assuming that the rate of prior infection with Mycobacterium tuberculosis was similar for HIV-1-seronegative and -seropositive populations, these data provide support for the recent recommendations to use induration of >5 mm as evidence of past infection with M. tuberculosis in HIV-1 seropositive adults.

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Tuberculin skin test reactivity among adults infected with human immunodeficiency virus

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