T MRI in Alzheimer's Disease: Detection of Pathological Changes in Medial Temporal Lobe

Mohammad Haris, Anup Singh, Kejia Cai, Erin Mcardle, Matthew Fenty, Christos Davatzikos, John Q. Trojanowski, Elias R. Melhem, Christopher M. Clark, Arijitt Borthakur

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


BACKGROUND: The need of an early and noninvasive diagnosis of AD requires the development of imaging-based techniques. As an alternative, the magnetic resonance image (MRI) relaxation time constant (T) was measured in brains of Alzheimer's disease (AD), mild-cognitive impairment (MCI), and age-matched controls in order to determine whether T values correlated with the neurological diagnosis. METHODS: MRI was performed on AD (n= 48), MCI (n= 45), and age-matched control (n= 41), on a 1.5 Tesla Siemens clinical MRI scanner. T maps were generated by fitting each pixel's intensity as a function of the duration of the spin-lock pulse. T values were calculated from the gray matter (GM) and white matter (WM) of medial temporal lobe (MTL). RESULTS: GM and WM T values were 87.5 ± 1.2 ms and 80.5 ± 1.4 ms, respectively, in controls, 90.9 ± 1.3 ms and 84.1 ± 1.7 ms in MCI, and 91.9 ± .8 ms and 88.3 ± 1.3 ms in AD cohorts. Compared to control, AD patients showed 9% increased WM T and 5% increased GM T. Compared to control, MCI individuals showed 4% increased T both in WM and GM. A 5% increased T was found in WM of AD over MCI. CONCLUSION: The increased T in WM and GM of MTL in AD may be associated with the pathological changes that are not evident on conventional MRI.

Original languageEnglish (US)
Pages (from-to)e86-e90
JournalJournal of Neuroimaging
Issue number2
StatePublished - Apr 2011
Externally publishedYes


  • Alzheimer's disease
  • MRI
  • Medial temporal lobe
  • T

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology


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