Trypanosoma cruzi meningoencephalitis in HIV-infected patients

Nanci Silva, Laura O'Bryan, Eduardo Medeiros, H. Holand, J. Suleiman, João Silva De Mendonca, Nicholas Patronas, Steven G. Reed, Harvey G. Klein, Henry Masur, Roberto Badaro

Research output: Contribution to journalArticlepeer-review

45 Scopus citations


Five cases of Trypanosoma cruzi meningoencephalitis in HIV-infected patients are reported. All patients presented with mass lesions on head computed tomographic scan, trypanosomes in the cerebrospinal fluid and failure to respond to antitoxoplasmosis therapy. Benznidazole therapy was associated with clinical improvement in 1 patient. Another 4 patients had T cruzi identified in a peripheral smear. T cruzi needs to be considered in the differential diagnosis of HIV-infected patients with central nervous system mass lesions if they have a history of appropriate exposure.

Original languageEnglish (US)
Pages (from-to)342-349
Number of pages8
JournalJournal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Issue number4
StatePublished - Apr 1 1999
Externally publishedYes


  • AIDS
  • Chagas' disease
  • HIV
  • Meningoencephalitis
  • Toxoplasmosis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Virology


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