Trypanosoma brucei: Four tandemly linked genes for fatty acyl-CoA synthetases

David W. Jiang, Roxann Ingersoll, Peter J. Myler, Paul T. Englund

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


We have cloned four acyl CoA synthetase (ACS) genes from Trypanosoma brucei strain 927. Each of these genes encodes a polypeptide about 78 kDa in size and all four contain the 'ACS signature motif.' Sequence alignments indicate that these proteins are 46%-95% identical in amino acid sequence. Interestingly, three of them share almost identical C-termini (about 215 amino acid residues). Southern blots suggest that these genes are present in a single copy, and Northern blots reveal that all four are expressed in both bloodstream and procyclic trypanosomes. (C) 2000 Academic Press.

Original languageEnglish (US)
Pages (from-to)16-22
Number of pages7
JournalExperimental Parasitology
Issue number1
StatePublished - 2000
Externally publishedYes

ASJC Scopus subject areas

  • Parasitology
  • Immunology
  • Infectious Diseases


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