True histiocytic lymphoma: A study of 12 cases based on Current definition

Onsi W. Kamel, Christopher D. Gocke, Donna L. Kell, Michael L. Cleary, Roger A. Warnke

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


True histiocytic lymphoma (THL), as it is currently defined, is a rare entity. We report 12 cases of THL seen at Stanford over the last ten years. By definition, the neoplastic cells in each case showed histological and immunological evidence of histiocytic differentiation. Seven females and five males ranged in age from 9 to 67 years. Sites of involvement included lymph node, soft tissue, bone, stomach, small intestine, mediastinum, kidney, breast and salivary gland. Lymph nodes showed diffuse architectural effacement and/or a paracortical pattern of involvement. The infiltrates involved other tissues in a diffuse pattern. Cytologically the cells were characterized by abundant eosinophilic cytoplasm and enlarged, indented eccentrically placed nuclei containing prominent nucleoli. In all cases the cytological features were sufficiently atypical to indicate a neoplastic infiltrate. Paraffin section immunophenotyping demonstrated reactivity of the atypical cells for CD15, 43, 45RO, 45RB, 68, lysozyme and/or S100. In frozen sections, the atypical cells demonstrated reactivity for CD4 (cytoplasmic), 11c, 14, 15, and/or 68. Genotypic studies were performed on 3 cases, one of which showed rearrangements of immunoglobulin heavy and light chain genes. Follow-up was available on eleven patients, six of whom died of disease 0.5 to 36 months following diagnosis.

Original languageEnglish (US)
Pages (from-to)81-86
Number of pages6
JournalLeukemia and Lymphoma
Issue number1-2
StatePublished - 1995
Externally publishedYes


  • Definition
  • True histiocytic lymphoma

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research


Dive into the research topics of 'True histiocytic lymphoma: A study of 12 cases based on Current definition'. Together they form a unique fingerprint.

Cite this