TRP trapped in fly signaling web

Craig Montell

Research output: Contribution to journalArticlepeer-review

86 Scopus citations


In the Drosophila eye, photoactivation of rhodopsin leads to the opening of the light-sensitive cation influx channels TRP and TRPL. This response is extremely rapid and results in depolarization of the photoreceptor cells followed by Ca2+-mediated feedback regulation of the visual signaling cascade. The mechanisms that facilitate the rapid kinetics of activation and feedback regulation are poorly understood. However, the recent discovery that most of the proteins that function in fly phototransduction associate into a supramolecular complex permits a re-evaluation of the mechanisms underlying the activation and regulation of the cascade. The central player in the signaling complex is INAD, a protein with five protein-interaction motifs known as PDZ domains. The INAD complex does not appear to be a particle, but a massive signaling web composed of an INAD polymer with which some of the target proteins associate through complex multivalent interactions.

Original languageEnglish (US)
Pages (from-to)389-397
Number of pages9
JournalCurrent Opinion in Neurobiology
Issue number3
StatePublished - Jun 1998

ASJC Scopus subject areas

  • Neuroscience(all)


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