Triptolide: Reflections on two decades of research and prospects for the future

Lu Tong; Qunfei Zhao; Emmanuel Datan; Guo Qiang Lin; Il Minn; Martin G. Pomper; Biao Yu; Daniel Romo; Qing Li He; Jun O. Liu

doi:10.1039/d0np00054j

Triptolide: Reflections on two decades of research and prospects for the future

Lu Tong, Qunfei Zhao, Emmanuel Datan, Guo Qiang Lin, Il Minn, Martin G. Pomper, Biao Yu, Daniel Romo, Qing Li He, Jun O. Liu

School of Medicine

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Abstract

Covering: 2000 to 2020 Triptolide is a bioactive diterpene triepoxide isolated from Tripterygium wilfordii Hook F, a traditional Chinese medicinal plant whose extracts have been used as anti-inflammatory and immunosuppressive remedies for centuries. Although triptolide and its analogs exhibit potent bioactivities against various cancers, and inflammatory and autoimmune diseases, none of them has been approved to be used in the clinic. This review highlights advances in material sourcing, molecular mechanisms, clinical progress and new drug design strategies for triptolide over the past two decades, along with some prospects for the future course of development of triptolide.

Original language	English (US)
Pages (from-to)	843-860
Number of pages	18
Journal	Natural Product Reports
Volume	38
Issue number	4
DOIs	https://doi.org/10.1039/d0np00054j
State	Published - Apr 2021

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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title = "Triptolide: Reflections on two decades of research and prospects for the future",

abstract = "Covering: 2000 to 2020 Triptolide is a bioactive diterpene triepoxide isolated from Tripterygium wilfordii Hook F, a traditional Chinese medicinal plant whose extracts have been used as anti-inflammatory and immunosuppressive remedies for centuries. Although triptolide and its analogs exhibit potent bioactivities against various cancers, and inflammatory and autoimmune diseases, none of them has been approved to be used in the clinic. This review highlights advances in material sourcing, molecular mechanisms, clinical progress and new drug design strategies for triptolide over the past two decades, along with some prospects for the future course of development of triptolide.",

author = "Lu Tong and Qunfei Zhao and Emmanuel Datan and Lin, {Guo Qiang} and Il Minn and Pomper, {Martin G.} and Biao Yu and Daniel Romo and He, {Qing Li} and Liu, {Jun O.}",

note = "Funding Information: This work was partially supported by NSFC (21977071), STCSM (18401933500, 19ZR1478400), SEMC (2019-01-07-00-10-E00072), the Opening Fund of State Key Lab of Bio-organic and Natural Products Chemistry, and the Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning (QH) and FAMRI (JOL). Publisher Copyright: {\textcopyright} The Royal Society of Chemistry.",

year = "2021",

month = apr,

doi = "10.1039/d0np00054j",

language = "English (US)",

volume = "38",

pages = "843--860",

journal = "Natural Product Reports",

issn = "0265-0568",

publisher = "Royal Society of Chemistry",

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T2 - Reflections on two decades of research and prospects for the future

AU - Tong, Lu

AU - Zhao, Qunfei

AU - Datan, Emmanuel

AU - Lin, Guo Qiang

AU - Minn, Il

AU - Pomper, Martin G.

AU - Yu, Biao

AU - Romo, Daniel

AU - He, Qing Li

AU - Liu, Jun O.

N1 - Funding Information: This work was partially supported by NSFC (21977071), STCSM (18401933500, 19ZR1478400), SEMC (2019-01-07-00-10-E00072), the Opening Fund of State Key Lab of Bio-organic and Natural Products Chemistry, and the Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning (QH) and FAMRI (JOL). Publisher Copyright: © The Royal Society of Chemistry.

PY - 2021/4

Y1 - 2021/4

N2 - Covering: 2000 to 2020 Triptolide is a bioactive diterpene triepoxide isolated from Tripterygium wilfordii Hook F, a traditional Chinese medicinal plant whose extracts have been used as anti-inflammatory and immunosuppressive remedies for centuries. Although triptolide and its analogs exhibit potent bioactivities against various cancers, and inflammatory and autoimmune diseases, none of them has been approved to be used in the clinic. This review highlights advances in material sourcing, molecular mechanisms, clinical progress and new drug design strategies for triptolide over the past two decades, along with some prospects for the future course of development of triptolide.

AB - Covering: 2000 to 2020 Triptolide is a bioactive diterpene triepoxide isolated from Tripterygium wilfordii Hook F, a traditional Chinese medicinal plant whose extracts have been used as anti-inflammatory and immunosuppressive remedies for centuries. Although triptolide and its analogs exhibit potent bioactivities against various cancers, and inflammatory and autoimmune diseases, none of them has been approved to be used in the clinic. This review highlights advances in material sourcing, molecular mechanisms, clinical progress and new drug design strategies for triptolide over the past two decades, along with some prospects for the future course of development of triptolide.

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Triptolide: Reflections on two decades of research and prospects for the future

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ASJC Scopus subject areas

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