@article{fa5903e7297b4993b409364bda2cc400,
title = "Trioxane dimers have potent antimalarial, antiproliferative and antitumor activities in vitro",
abstract = "A series of tetracyclic and tricyclic trioxane dimers has been prepared with ether and ester tethers of varying length and flexibility. Several of these trioxane dimers have been found to have potent and potentially therapeutically valuable antimalarial, antiproliferative, and antitumor activities in vitro.",
author = "Posner, {Gary H.} and Poonsakdi Ploypradith and Whitney Hapangama and Dasong Wang and Cumming, {Jared N.} and Patrick Dolan and Kensler, {Thomas W.} and Donna Klinedinst and Shapiro, {Theresa A.} and Zheng, {Qun Yi} and Murray, {Christopher K.} and Pilkington, {Lynn G.} and Jayasinghe, {Lalith R.} and Bray, {Jeff F.} and Randy Daughenbaugh",
note = "Funding Information: We thank the NIH (AI-34885, CA-44530, and NCRR, OPD-GCRC RR00722) and the Burroughs Wellcome Fund for the support of part of this research at the Johns Hopkins University. We also thank the NCI's Developmental and Therapeutics program for the evaluation of these dimers, and Dr Yong Kim (JHU) for critical insights.",
year = "1997",
month = jul,
doi = "10.1016/S0968-0896(97)00079-5",
language = "English (US)",
volume = "5",
pages = "1257--1265",
journal = "Bioorganic and Medicinal Chemistry",
issn = "0968-0896",
publisher = "Elsevier Limited",
number = "7",
}