Trifluorothymidine treatment of herpes simplex epithelial keratitis and comparison with idoxuridine

J. Sugar, W. Stark, P. S. Binder

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


In a double-masked evaluation, trifluorothymidine (F3T) was as effective as idoxuridine (IDU). Ninety-two percent of dendritic lesions healed with F3T while 83% healed with IDU. Seventy-five percent of geographic ulcers healed with F3T and 33% with IDU, but this difference was not statistically significant. More important, an open evaluation of F3T in patients with allergy to IDU or herpes simplex epithelial keratitis unresponsive to IDU or vidarabine demonstrated healing of 100% of dendritic and 85% of geographic ulcers. F3T is an effective alternative to IDU and vidarabine in the treatment of herpes simplex keratitis for patients who have developed toxic or allergic changes to those drugs or who fail to respond to them.

Original languageEnglish (US)
Pages (from-to)611-615
Number of pages5
JournalAnnals of ophthalmology
Issue number6
StatePublished - Jan 1 1980

ASJC Scopus subject areas

  • Ophthalmology


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