TY - JOUR
T1 - Tricyclic antidepressants and cognitive decline
AU - Podewils, Laura Jean
AU - Lyketsos, Constantine G.
N1 - Funding Information:
This study was supported by NIMH ( MH-47447 ) for the Baltimore ECA follow-up.
PY - 2002
Y1 - 2002
N2 - In this study, we sought to determine the cross-sectional and longitudinal relations of tricyclic antidepressant (TCA) use to cognitive function and cognitive change in a population-based sample of adults (n = 1, 488). Sociodemographic information, TCA use, and baseline scores on the Mini-Mental State Exam (MMSE) were determined in the initial two waves of the study. At wave 3, participants repeated the MMSE; the prospective relation was assessed for change between waves 2 and 3 (median 11.5 years). These findings failed to support the concept that TCA use is related to concurrent measurable cognitive deficits, and TCA use does not appear to significantly compromise memory over a substantial time span.
AB - In this study, we sought to determine the cross-sectional and longitudinal relations of tricyclic antidepressant (TCA) use to cognitive function and cognitive change in a population-based sample of adults (n = 1, 488). Sociodemographic information, TCA use, and baseline scores on the Mini-Mental State Exam (MMSE) were determined in the initial two waves of the study. At wave 3, participants repeated the MMSE; the prospective relation was assessed for change between waves 2 and 3 (median 11.5 years). These findings failed to support the concept that TCA use is related to concurrent measurable cognitive deficits, and TCA use does not appear to significantly compromise memory over a substantial time span.
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U2 - 10.1176/appi.psy.43.1.31
DO - 10.1176/appi.psy.43.1.31
M3 - Article
C2 - 11927755
AN - SCOPUS:0036184878
SN - 0033-3182
VL - 43
SP - 31
EP - 35
JO - Psychosomatics
JF - Psychosomatics
IS - 1
ER -