Tricyclic antidepressant drug interactions with histamine and α-adrenergic receptors

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13 Scopus citations


Tricyclic antidepressant drugs are remarkable in their therapeutic actions. When given acutely they are generally sedating. Then after a lag of 1-3 weeks, they alleviate depressive symptoms. Besides the delayed psychic energizing properties, the immediate apparent sedative actions may have importance for the relief of psychomotor agitation. This article describes influences of the drugs on histamine H1 and α-adrenergic receptors which may be of relevance to the energizing effects and relief of psychomotor agitation.

Original languageEnglish (US)
Pages (from-to)62-67
Number of pages6
JournalPharmakopsychiatrie und Neuropsychopharmakologie
Issue number2
StatePublished - 1980

ASJC Scopus subject areas

  • Medicine(all)


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