Trichomonosis and subsequent risk of prostate cancer in the Prostate Cancer Prevention Trial

Siobhan Sutcliffe, John F. Alderete, Cathee Till, Phyllis J. Goodman, Ann W. Hsing, Jonathan M. Zenilman, Angelo M. De Marzo, Elizabeth A. Platz

Research output: Contribution to journalArticlepeer-review

63 Scopus citations


We previously observed a positive association between a history of trichomonosis, a sexually transmitted infection caused by the protozoan, Trichomonas vaginalis, and prostate cancer risk in the Health Professionals Follow-up Study. To determine the reproducibility of this finding, we conducted a second, prospective investigation of trichomonosis and prostate cancer in the Prostate Cancer Prevention Trial. Participants were men (≥55 years of age) with no evidence of prostate cancer at enrollment (n = 18,882). Men were screened annually for prostate cancer, and if not diagnosed during the trial, were offered an end-of-study prostate biopsy. Cases were a sample of men diagnosed with prostate cancer on any biopsy after visit 2 or on their end-of-study biopsy (n = 616). Controls were men not diagnosed with prostate cancer during the trial or on their end-of-study biopsy (n = 616). Controls were frequency-matched to cases by age, treatment arm, and family history of prostate cancer. Serum from visit 2 was tested for anti-T. vaginalis IgG antibodies. No association was observed between T. vaginalis serostatus and prostate cancer. 21.5% of cases and 24.8% of controls had low seropositivity, and 15.2% and 15.0% had high seropositivity. Compared to seronegative men, the odds ratio of prostate cancer for men with low seropositivity was 0.83 [95% confidence interval (CI): 0.63-1.09), and that for men with high seropositivity was 0.97 (95% CI: 0.70-1.34). Given the original strong biologic rationale and potential for prevention, additional studies are warranted to help resolve discrepancies between study findings and to further investigate this hypothesis from a variety of different approaches.

Original languageEnglish (US)
Pages (from-to)2082-2087
Number of pages6
JournalInternational Journal of Cancer
Issue number9
StatePublished - May 1 2009


  • Epidemiology
  • Prostate cancer
  • Sexually transmitted infection
  • Trichomonas vaginalis
  • Trichomonosis

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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