TY - JOUR
T1 - Trefoil factor 2 rapidly induces interleukin 33 to promote type 2 immunity during allergic asthma and hookworm infection
AU - Wills-Karp, Marsha
AU - Rani, Reena
AU - Dienger, Krista
AU - Lewkowich, Ian
AU - Fox, James G.
AU - Perkins, Charles
AU - Lewis, Lauren
AU - Finkelman, Fred D.
AU - Smith, Dirk E.
AU - Bryce, Paul J.
AU - Kurt-Jones, Evelyn A.
AU - Wang, Timothy C.
AU - Sivaprasad, Umasundari
AU - Hershey, Gurjit K.
AU - Herbert, De'Broski R.
PY - 2012/3/12
Y1 - 2012/3/12
N2 - The molecular mechanisms that drive mucosal T helper type 2 (T H2) responses against parasitic helminths and allergens remain unclear. In this study, we demonstrate in mice that TFF2 (trefoil factor 2), an epithelial cell-derived repair molecule, is needed for the control of lung injury caused by the hookworm parasite Nippostrongylus brasiliensis and for type 2 immunity after infection. TFF2 is also necessary for the rapid production of IL-33, a T H2-promoting cytokine, by lung epithelia, alveolar macrophages, and inflammatory dendritic cells in infected mice. TFF2 also increases the severity of allergic lung disease caused by house dust mite antigens or IL-13. Moreover, TFF2 messenger RNA expression is significantly increased in nasal mucosal brushings during asthma exacerbations in children. These experiments extend the biological functions of TFF2 from tissue repair to the initiation and maintenance of mucosal T H2 responses.
AB - The molecular mechanisms that drive mucosal T helper type 2 (T H2) responses against parasitic helminths and allergens remain unclear. In this study, we demonstrate in mice that TFF2 (trefoil factor 2), an epithelial cell-derived repair molecule, is needed for the control of lung injury caused by the hookworm parasite Nippostrongylus brasiliensis and for type 2 immunity after infection. TFF2 is also necessary for the rapid production of IL-33, a T H2-promoting cytokine, by lung epithelia, alveolar macrophages, and inflammatory dendritic cells in infected mice. TFF2 also increases the severity of allergic lung disease caused by house dust mite antigens or IL-13. Moreover, TFF2 messenger RNA expression is significantly increased in nasal mucosal brushings during asthma exacerbations in children. These experiments extend the biological functions of TFF2 from tissue repair to the initiation and maintenance of mucosal T H2 responses.
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U2 - 10.1084/jem.20110079
DO - 10.1084/jem.20110079
M3 - Article
C2 - 22329990
AN - SCOPUS:84860357324
SN - 0022-1007
VL - 209
SP - 607
EP - 622
JO - Journal of Experimental Medicine
JF - Journal of Experimental Medicine
IS - 3
ER -