Treatment of Sympathomimetic Induced Intraventricular Hemorrhage with Intraventricular Urokinase

Wendy C. Ziai, Antigone Triantaphyllopoulou, Alexander Y. Razumovsky, Daniel F. Hanley

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Intraventricular hemorrhage (IVH) occurred in a 32-year-old man following the use of both ephedrine and pseudoephedrine. Cerebral angiography and transcranial Doppler studies showed changes suggestive of vasculitis. We describe the management and investigations of a unique case of IVH. This patient was treated with ventriculostomy and intraventricular urokinase (UK). A favorable outcome was obtained with independent function at 10 weeks post hemorrhage. The use of intraventricular thrombolysis for drug-induced IVH has not previously been reported, although it has been shown to be a safe and potentially beneficial intervention.

Original languageEnglish (US)
Pages (from-to)276-279
Number of pages4
JournalJournal of Stroke and Cerebrovascular Diseases
Issue number6
StatePublished - 2003


  • Intraventricular hemorrhage
  • Sympathomimetics
  • Thrombolysis
  • Urokinase

ASJC Scopus subject areas

  • Surgery
  • Rehabilitation
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine


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