Treatment of human polyomavirus-7-associated rash and pruritus with topical cidofovir in a lung transplant patient: Case report and literature review

Shane D.B. Smith; Gulsun Erdag; Jonathan D. Cuda; Sophie Rangwala; Nicholas Girardi; Kristin Bibee; Jonathan B. Orens; Maria Dioverti Prono; Tuna Toptan; Manisha J. Loss

doi:10.1111/tid.12793

Treatment of human polyomavirus-7-associated rash and pruritus with topical cidofovir in a lung transplant patient: Case report and literature review

Shane D.B. Smith, Gulsun Erdag, Jonathan D. Cuda, Sophie Rangwala, Nicholas Girardi, Kristin Bibee, Jonathan B. Orens, Maria Dioverti Prono, Tuna Toptan, Manisha J. Loss

School of Medicine

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Human polyomavirus-7-associated rash and pruritus (PVARP) is a chronic superficial viral skin infection, which primarily impacts immunocompromised individuals. We report on a case of PVARP in a lung transplant recipient. Our patient developed symptoms 13 years after being on his immunosuppressive regimen, with an insidious course of progressive gray lichenification with marked islands of sparing and quality of life-altering pruritus. Treatment for PVARP is not established; however, topical cidofovir combined with immunomodulation may offer sustained therapeutic benefit.

Original language	English (US)
Article number	e12793
Journal	Transplant Infectious Disease
Volume	20
Issue number	1
DOIs	https://doi.org/10.1111/tid.12793
State	Published - Feb 2018

Keywords

cidofovir
human polyomavirus-7
peacock plumage
pruritus
rash
solid organ transplantation

ASJC Scopus subject areas

Transplantation
Infectious Diseases

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10.1111/tid.12793

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Smith, S. D. B., Erdag, G., Cuda, J. D., Rangwala, S., Girardi, N., Bibee, K., Orens, J. B., Prono, M. D., Toptan, T., & Loss, M. J. (2018). Treatment of human polyomavirus-7-associated rash and pruritus with topical cidofovir in a lung transplant patient: Case report and literature review. Transplant Infectious Disease, 20(1), Article e12793. https://doi.org/10.1111/tid.12793

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abstract = "Human polyomavirus-7-associated rash and pruritus (PVARP) is a chronic superficial viral skin infection, which primarily impacts immunocompromised individuals. We report on a case of PVARP in a lung transplant recipient. Our patient developed symptoms 13 years after being on his immunosuppressive regimen, with an insidious course of progressive gray lichenification with marked islands of sparing and quality of life-altering pruritus. Treatment for PVARP is not established; however, topical cidofovir combined with immunomodulation may offer sustained therapeutic benefit.",

keywords = "cidofovir, human polyomavirus-7, peacock plumage, pruritus, rash, solid organ transplantation",

author = "Smith, {Shane D.B.} and Gulsun Erdag and Cuda, {Jonathan D.} and Sophie Rangwala and Nicholas Girardi and Kristin Bibee and Orens, {Jonathan B.} and Prono, {Maria Dioverti} and Tuna Toptan and Loss, {Manisha J.}",

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doi = "10.1111/tid.12793",

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AU - Erdag, Gulsun

AU - Cuda, Jonathan D.

AU - Rangwala, Sophie

AU - Girardi, Nicholas

AU - Bibee, Kristin

AU - Orens, Jonathan B.

AU - Prono, Maria Dioverti

AU - Toptan, Tuna

AU - Loss, Manisha J.

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AB - Human polyomavirus-7-associated rash and pruritus (PVARP) is a chronic superficial viral skin infection, which primarily impacts immunocompromised individuals. We report on a case of PVARP in a lung transplant recipient. Our patient developed symptoms 13 years after being on his immunosuppressive regimen, with an insidious course of progressive gray lichenification with marked islands of sparing and quality of life-altering pruritus. Treatment for PVARP is not established; however, topical cidofovir combined with immunomodulation may offer sustained therapeutic benefit.

KW - cidofovir

KW - human polyomavirus-7

KW - peacock plumage

KW - pruritus

KW - rash

KW - solid organ transplantation

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Treatment of human polyomavirus-7-associated rash and pruritus with topical cidofovir in a lung transplant patient: Case report and literature review

Abstract

Keywords

ASJC Scopus subject areas

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