TY - JOUR
T1 - Treatment of human immunodeficiency virus infection with hydroxyurea, didanosine, and a protease inhibitor before seroconversion is associated with normalized immune parameters and limited viral reservoir
AU - Lori, Franco
AU - Jessen, Heiko
AU - Lieberman, Judy
AU - Finzi, Diana
AU - Rosenberg, Eric
AU - Tinelli, Carmine
AU - Walker, Bruce
AU - Siliciano, Robert F.
AU - Lisziewicz, Julianna
N1 - Funding Information:
All patients provided signed informed consent before the start of treatment. The protocol was approved by institutional review boards of the authors’ institutions. Human experimentation guidelines of the US Department of Health and Human Services and of the authors’ institutions were followed in the conduct of clinical research, as were the principles outlined in the Declaration of Helsinki (1990). Grant support: ISS (grant 30.A.0.32); Bristol-Myers Squibb.
PY - 1999
Y1 - 1999
N2 - Current treatments for human immunodeficiency virus (HIV) require uninterrupted drug administration because they are unable to reconstitute the immune response and do not affect the viral reservoir. Ten patients were treated during acute HIV infection before complete Western blot (WB) seroconversion with the combination of hydroxyurea, didanosine, and indinavir. This treatment was associated with the normalization of some immune parameters and functions. No loss of naive CD4 T lymphocytes was observed, and recovery of up to 35% of naive CD8 T lymphocytes occurred in several weeks. A vigorous HIV-specific T helper response (stimulation index >8) was observed in 7 of 8 patients treated before complete WB seroconversion but in only 1 of 5 controls treated after seroconversion. In addition, a limited latent viral reservoir (<0.02-0.5 infectious units/105 cells) was documented in quiescent peripheral blood lymphocytes after treatment initiated before complete WB seroconversion.
AB - Current treatments for human immunodeficiency virus (HIV) require uninterrupted drug administration because they are unable to reconstitute the immune response and do not affect the viral reservoir. Ten patients were treated during acute HIV infection before complete Western blot (WB) seroconversion with the combination of hydroxyurea, didanosine, and indinavir. This treatment was associated with the normalization of some immune parameters and functions. No loss of naive CD4 T lymphocytes was observed, and recovery of up to 35% of naive CD8 T lymphocytes occurred in several weeks. A vigorous HIV-specific T helper response (stimulation index >8) was observed in 7 of 8 patients treated before complete WB seroconversion but in only 1 of 5 controls treated after seroconversion. In addition, a limited latent viral reservoir (<0.02-0.5 infectious units/105 cells) was documented in quiescent peripheral blood lymphocytes after treatment initiated before complete WB seroconversion.
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U2 - 10.1086/315113
DO - 10.1086/315113
M3 - Article
C2 - 10558937
AN - SCOPUS:0032710328
SN - 0022-1899
VL - 180
SP - 1827
EP - 1832
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 6
ER -