Treatment Deintensification Strategies for HPV-Associated Head and Neck Carcinomas

Harry Quon, Jeremy D. Richmon

Research output: Contribution to journalReview articlepeer-review

40 Scopus citations


Past treatment efforts for head and neck squamous cell carcinomas have emphasized treatment intensification that increased local-regional control rates with an increased risk of late (swallowing) complications. With the improved survival demonstrated for human papillomavirus-related oropharyngeal carcinomas, strategies offering comparable outcomes but with fewer complications are needed. Radiotherapy dose reduction has been postulated to reduce the risk of late complications and is an active area of investigation. Alternative strategies may include the use of transoral surgery offering selective use of adjuvant therapy. This article summarizes the contributing risk factors of late swallowing complications and the strategies for risk reduction.

Original languageEnglish (US)
Pages (from-to)845-861
Number of pages17
JournalOtolaryngologic Clinics of North America
Issue number4
StatePublished - Aug 1 2012


  • De-intensification
  • HPV-associated head and neck carcinoma
  • Late swallowing complications
  • Radiotherapy
  • Treatment complications
  • Treatment deintensfication

ASJC Scopus subject areas

  • Otorhinolaryngology


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