Treatment De-intensification in HPV-Associated Oropharyngeal Cancer: Evidence, Controversies, and Strategies

Virginia Diavolitsis, Harry Quon

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


A subset of oropharyngeal squamous cell carcinomas (OPSCC) has been shown to be related to human papillomavirus (HPV). These cancers have improved prognosis compared to non-HPV-associated OPSCC. The recognition of this favorable prognosis cohort of patients has occurred in the midst of decades of investigations seeking to intensify local-regional therapy to improve tumor control and survival rates. With long-term follow-up, it is now clear that these intensification strategies are associated with significant late toxicities prompting a re-evaluation of the role of intensified local-regional therapy for HPV-associated OPSCC. The de-intensification strategies that have been evaluated or currently under evaluation are reviewed in this article.

Original languageEnglish (US)
Pages (from-to)47-55
Number of pages9
JournalCurrent Otorhinolaryngology Reports
Issue number2
StatePublished - Jun 2015


  • Chemotherapy
  • Human papilloma virus
  • Oropharyngeal carcinoma
  • Radiation therapy
  • Radiotherapy dose de-escalation
  • Treatment de-intensification

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Surgery
  • Immunology and Allergy
  • Clinical Neurology


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