Treating Chronic Pain with Buprenorphine—The Practical Guide

Amy A. Case, Justin Kullgren, Sidra Anwar, Sandra Pedraza, Mellar P. Davis

Research output: Contribution to journalReview articlepeer-review


Buprenorphine has unique and favorable pharmacological properties that make it useful in a variety of clinical scenarios. It has been recommended to consider buprenorphine first-line opioid for chronic pain, especially in the elderly as it may be associated with less cognitive impairment, falls, sexual dysfunction, and sarcopenia when compared with schedule II opioids. It may be useful in patients with comorbid substance use disorder or non-medical opioid use, as there is less risk of misuse, euphoria and it may improve mood. When used to treat opioid use disorder, the training and waiver was recently waived for licensed practitioners with a DEA and any provider may prescribe buprenorphine. For many reasons outlined in this article, the popularity of using buprenorphine for analgesia continues to grow and a practitioner should consider this as an excellent and safe option for chronic pain.

Original languageEnglish (US)
Article number116
JournalCurrent treatment options in oncology
Issue number12
StatePublished - Dec 2021
Externally publishedYes


  • Buprenorphine
  • Chronic pain
  • Microdosing
  • Opioid

ASJC Scopus subject areas

  • Oncology
  • Pharmacology (medical)


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