Treadmill endurance during 2-year treatment with tiotropium in patients with COPD: A randomized trial

Christopher B. Cooper, Bartolome R. Celli, José R. Jardim, Robert A. Wise, Daniel Legg, Junhai Guo, Steven Kesten

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


Background: Disease progression in COPD is associated with a decline in exercise performance over time. We assessed whether tiotropium might mitigate this by determining its effect on treadmill endurance time (ET) over 2 years. Methods: This was a randomized, double-blind, placebo-controlled trial of tiotropium, 18 m g daily, in patients with COPD (FEV 1 /FVC < 70%; postbronchodilator FEV 1 < 65%). The primary end point was ET at 90% of baseline maximum work rate at 96 weeks. Secondary end points were ET at other visits, ET by smoking status, spirometry, and St. George's Respiratory Questionnaire (SGRQ). Results: A total of 519 patients were randomized (tiotropium 260, placebo 259). Mean age was 65 years, 77% were men, 34% were continuing smokers, and mean FEV 1 was 1.25 L (44% predicted). Signifi cantly more patients discontinued placebo (hazard ratio [95% CI], 0.61 [0.44-0.83]). Baseline ET was 301 s (improvement tiotropium/placebo was 13% overall; P = .009; 18% at 48 weeks, P = .004; 13% at 96 weeks, P = .106). In patients with baseline ET between 2 and 10 min (n = 404), improvement at 96 weeks was 19% (P = .04). Current smokers had higher ET with tiotropium vs placebo (P = .018). FEV 1 /FVC improved with tiotropium (P < .01). SGRQ total score at 96 weeks improved with tiotropium vs placebo by 4.03 units (P = .007). Conclusions: Treadmill ET was numerically greater over 2 years with tiotropium vs placebo. However, the 96-week difference was not statistically signifi cant. Spirometry and health status also improved with tiotropium over 2 years, attesting to the benefi ts of long-acting bronchodilator therapy.

Original languageEnglish (US)
Pages (from-to)490-497
Number of pages8
Issue number2
StatePublished - Aug 2013

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine


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