TY - JOUR
T1 - Traumatic brain injury in the rat using the fluid-percussion model.
AU - Ling, Geoffrey S.F.
AU - Lee, Eleanor Y.
AU - Kalehua, Audrey N.
PY - 2004/9
Y1 - 2004/9
N2 - Traumatic brain injury is a leading cause of death and disability, particularly among young adults. During closed head trauma, the injury process is initiated by the impact of the brain against the inner table of the calvarium. Subsequently, there is prompt initiation of a complex biochemical, cellular, and physiological injury cascade that may take days to complete. From a functional standpoint, this culminates in neurologic dysfunction and, if severe, death. This unit describes an impact-induced brain trauma model in rats which replicates nonpenetrating head injury. It does not model either penetrating or ischemic brain injuries.
AB - Traumatic brain injury is a leading cause of death and disability, particularly among young adults. During closed head trauma, the injury process is initiated by the impact of the brain against the inner table of the calvarium. Subsequently, there is prompt initiation of a complex biochemical, cellular, and physiological injury cascade that may take days to complete. From a functional standpoint, this culminates in neurologic dysfunction and, if severe, death. This unit describes an impact-induced brain trauma model in rats which replicates nonpenetrating head injury. It does not model either penetrating or ischemic brain injuries.
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U2 - 10.1002/0471142301.ns0902s28
DO - 10.1002/0471142301.ns0902s28
M3 - Article
C2 - 18428615
AN - SCOPUS:43149124001
SN - 1934-8584
VL - Chapter 9
SP - Unit 9.2
JO - Current protocols in neuroscience / editorial board, Jacqueline N. Crawley ... [et al.]
JF - Current protocols in neuroscience / editorial board, Jacqueline N. Crawley ... [et al.]
ER -