Transport of Fluorescein in the Ocular Posterior Segment in Retinitis Pigmentosa

Kim S. Mallick; Ran C. Zeimer; Gerald A. Fishman; Norman P. Blair; Robert J. Anderson

doi:10.1001/archopht.1984.01040030547013

Transport of Fluorescein in the Ocular Posterior Segment in Retinitis Pigmentosa

Kim S. Mallick, Ran C. Zeimer, Gerald A. Fishman, Norman P. Blair, Robert J. Anderson

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

The function of the blood-retinal barrier was assessed by vitreous fluorophotometry in 12 patients with various genetic types of retinitis pigmentosa and in 11 normal subjects. The measurements were corrected to minimize the effect of artifacts. We evaluated the inward penetration of fluorescein sodium across the blood-retinal barrier and determined the outward permeability coefficient for fluorescein by interpreting the data with a pharmacokinetic computer model. Patients with retinitis pigmentosa had increased inward permeability and decreased outward permeability to fluorescein in comparison with values of normal subjects.

Original language	English (US)
Pages (from-to)	691-696
Number of pages	6
Journal	Archives of ophthalmology
Volume	102
Issue number	5
DOIs	https://doi.org/10.1001/archopht.1984.01040030547013
State	Published - May 1984
Externally published	Yes

ASJC Scopus subject areas

Ophthalmology

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10.1001/archopht.1984.01040030547013

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AU - Blair, Norman P.

AU - Anderson, Robert J.

PY - 1984/5

Y1 - 1984/5

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AB - The function of the blood-retinal barrier was assessed by vitreous fluorophotometry in 12 patients with various genetic types of retinitis pigmentosa and in 11 normal subjects. The measurements were corrected to minimize the effect of artifacts. We evaluated the inward penetration of fluorescein sodium across the blood-retinal barrier and determined the outward permeability coefficient for fluorescein by interpreting the data with a pharmacokinetic computer model. Patients with retinitis pigmentosa had increased inward permeability and decreased outward permeability to fluorescein in comparison with values of normal subjects.

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Transport of Fluorescein in the Ocular Posterior Segment in Retinitis Pigmentosa

Abstract

ASJC Scopus subject areas

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