Transport of cholecystokinin (CCK) binding sites in subdiaphragmatic vagal branches

Timothy H. Moran; Gerard P. Smith; Anne M. Hostetler; Paul R. McHugh

doi:10.1016/0006-8993(87)90278-2

Transport of cholecystokinin (CCK) binding sites in subdiaphragmatic vagal branches

Timothy H. Moran, Gerard P. Smith, Anne M. Hostetler, Paul R. McHugh

School of Medicine

Research output: Contribution to journal › Article › peer-review

157 Scopus citations

Abstract

In order to evaluate vagal cholecystokinin (CCK) binding sites as potential target sites for the satiety actions of CCK, their presence, axonal flow and pharmacological specificity in subdiaphragmatic vagal branches were examined by autoradiography utilizing ¹²⁵I-Bolton Hunter CCK-33. Specific CCK binding and axonal transport were found in vagal trunks and all abdominal vagal branches. Binding was inhibited by unlabelled CCK-8, but not by desulfated CCK-8. The pharmacological specificity and transport of CCK binding sites to subdiaphragmatic branches indicate a potential role in mediating CCK's satiety effect.

Original language	English (US)
Pages (from-to)	149-152
Number of pages	4
Journal	Brain research
Volume	415
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(87)90278-2
State	Published - Jul 7 1987

Keywords

Cholecystokinin
Receptor
Satiety
Vagus

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(87)90278-2

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title = "Transport of cholecystokinin (CCK) binding sites in subdiaphragmatic vagal branches",

abstract = "In order to evaluate vagal cholecystokinin (CCK) binding sites as potential target sites for the satiety actions of CCK, their presence, axonal flow and pharmacological specificity in subdiaphragmatic vagal branches were examined by autoradiography utilizing 125I-Bolton Hunter CCK-33. Specific CCK binding and axonal transport were found in vagal trunks and all abdominal vagal branches. Binding was inhibited by unlabelled CCK-8, but not by desulfated CCK-8. The pharmacological specificity and transport of CCK binding sites to subdiaphragmatic branches indicate a potential role in mediating CCK's satiety effect.",

keywords = "Cholecystokinin, Receptor, Satiety, Vagus",

author = "Moran, {Timothy H.} and Smith, {Gerard P.} and Hostetler, {Anne M.} and McHugh, {Paul R.}",

note = "Funding Information: This work was supported by NIH Grant AM19302 (P.R.M.) and NIMH Grants MH40010 and MH00149 (G.P.S.).",

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doi = "10.1016/0006-8993(87)90278-2",

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T1 - Transport of cholecystokinin (CCK) binding sites in subdiaphragmatic vagal branches

AU - Moran, Timothy H.

AU - Smith, Gerard P.

AU - Hostetler, Anne M.

AU - McHugh, Paul R.

N1 - Funding Information: This work was supported by NIH Grant AM19302 (P.R.M.) and NIMH Grants MH40010 and MH00149 (G.P.S.).

PY - 1987/7/7

Y1 - 1987/7/7

N2 - In order to evaluate vagal cholecystokinin (CCK) binding sites as potential target sites for the satiety actions of CCK, their presence, axonal flow and pharmacological specificity in subdiaphragmatic vagal branches were examined by autoradiography utilizing 125I-Bolton Hunter CCK-33. Specific CCK binding and axonal transport were found in vagal trunks and all abdominal vagal branches. Binding was inhibited by unlabelled CCK-8, but not by desulfated CCK-8. The pharmacological specificity and transport of CCK binding sites to subdiaphragmatic branches indicate a potential role in mediating CCK's satiety effect.

AB - In order to evaluate vagal cholecystokinin (CCK) binding sites as potential target sites for the satiety actions of CCK, their presence, axonal flow and pharmacological specificity in subdiaphragmatic vagal branches were examined by autoradiography utilizing 125I-Bolton Hunter CCK-33. Specific CCK binding and axonal transport were found in vagal trunks and all abdominal vagal branches. Binding was inhibited by unlabelled CCK-8, but not by desulfated CCK-8. The pharmacological specificity and transport of CCK binding sites to subdiaphragmatic branches indicate a potential role in mediating CCK's satiety effect.

KW - Cholecystokinin

KW - Receptor

KW - Satiety

KW - Vagus

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JO - Brain Research

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Transport of cholecystokinin (CCK) binding sites in subdiaphragmatic vagal branches

Abstract

Keywords

ASJC Scopus subject areas

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