Transplantation Antibodies in Human Recipients of Renal Homografts

George M. Williams, David M. Hume, Kyoichi Kano, Felix Milgrom

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Transplantation antibodies in the sera of eight patients who survived rejection of one or two renal grafts were studied by the mixed agglutination tests with cell cultures. Evidence that transplantation antibodies are removed from the recipient's circulation by the functioning graft was as follows: (1) the antibodies were detected in sera of the patients during the terminal stage of rejection or after the removal of the graft but never during the normal function of the graft; (2) the antibodies could be eluted from the rejected grafts. Present data also brought some evidence for the possible participation of humoral antibodies in rejection of renal grafts.

Original languageEnglish (US)
Pages (from-to)119-122
Number of pages4
JournalJAMA: The Journal of the American Medical Association
Volume204
Issue number2
DOIs
StatePublished - Apr 8 1968
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine

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