TY - JOUR
T1 - Transplantation
T2 - All for one and one for all-alloimmunization and polyreactivity
AU - Montgomery, Robert A.
AU - Zachary, Andrea A.
PY - 2012/8/1
Y1 - 2012/8/1
N2 - In a new study, Porcheray et al. provide evidence that a single antibody generated by alloimmunization can recognize multiple antigens in a paradigm-changing fashion. Although these results require confirmation, the presence of polyreactive antibody may offer an explanation as to why some patients with a single sensitizing event develop a wide breadth of panel-reactive antibody.
AB - In a new study, Porcheray et al. provide evidence that a single antibody generated by alloimmunization can recognize multiple antigens in a paradigm-changing fashion. Although these results require confirmation, the presence of polyreactive antibody may offer an explanation as to why some patients with a single sensitizing event develop a wide breadth of panel-reactive antibody.
UR - http://www.scopus.com/inward/record.url?scp=84864327010&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84864327010&partnerID=8YFLogxK
U2 - 10.1038/nrneph.2012.140
DO - 10.1038/nrneph.2012.140
M3 - Article
C2 - 22777202
AN - SCOPUS:84864327010
SN - 1759-5061
VL - 8
SP - 442
EP - 443
JO - Nature Reviews Nephrology
JF - Nature Reviews Nephrology
IS - 8
ER -