Transmission of hepatitis B by transplantation of livers from donors positive for antibody to hepatitis B core antigen

R. C. Dickson; J. E. Everhart; J. R. Lake; Y. Wei; E. C. Seaberg; R. H. Wiesner; R. K. Zetterman; T. L. Pruett; M. B. Ishitani; J. H. Hoofnagle; K. M. Detre; A. J. Demetris; S. Belle; Y. Wei; M. Lombardero; E. Seaberg; S. Lawlor; H. Eng; S. Fitzgerald; J. Haber; G. L. Swanson; R. Wiesner; R. Krom; M. K. Porayko; L. Schwerman; C. Groettum; R. K. Zetterman; Jr Shaw B.; K. Taylor; N. Ascher; J. Lake; C. Bremer-Kamp; J. Everhart; S. Shores

doi:10.1053/gast.1997.v113.pm9352871

Transmission of hepatitis B by transplantation of livers from donors positive for antibody to hepatitis B core antigen

R. C. Dickson, J. E. Everhart, J. R. Lake, Y. Wei, E. C. Seaberg, R. H. Wiesner, R. K. Zetterman, T. L. Pruett, M. B. Ishitani, J. H. Hoofnagle, K. M. Detre, A. J. Demetris, S. Belle, Y. Wei, M. Lombardero, E. Seaberg, S. Lawlor, H. Eng, S. Fitzgerald, J. HaberG. L. Swanson, R. Wiesner, R. Krom, M. K. Porayko, L. Schwerman, C. Groettum, R. K. Zetterman, Jr Shaw B., K. Taylor, N. Ascher, J. Lake, C. Bremer-Kamp, J. Everhart, S. Shores

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Abstract

Background and Aims: Organ donors are a potential source of transmissible disease after transplantation. The aim of this study was to evaluate the risk of acquiring hepatitis B among transplantation recipients of livers from donors without serum hepatitis B surface antigen (HBsAg) but with antibody to hepatitis B core antigen (anti-HBc). Methods: The transplantation experience of four centers between 1989 and 1994 was reviewed. Recipients of livers from 674 donors were considered informative for hepatitis B virus transmission. Results: Hepatitis B developed in 18 of 23 recipients of livers from anti-HBc-positive donors (78%) compared with only 3 of 651 recipients of anti-HBc-negative donor livers (0.5%) (P < 0.0001). HBsAg persisted in all recipients with donor-related hepatitis B. Liver histology showed chronic hepatitis of moderate severity in 2 of 13 recipients at 1 year and 5 of 8 recipients between 1.6 and 4.5 years from transplantation. Liver transplantation from an anti-HBc-positive donor was associated with decreased 4-year survival (adjusted mortality hazard ratio of 2.4; 95% confidence interval, 1.44.0). Conclusions: De novo posttransplantation hepatitis B infection occurs at a high rate in recipients of donors with anti-HBc. Transmission of hepatitis B through transplantation suggests that the virus may persist in the liver despite serological resolution of infection.

Original language	English (US)
Pages (from-to)	1668-1674
Number of pages	7
Journal	Gastroenterology
Volume	113
Issue number	5
DOIs	https://doi.org/10.1053/gast.1997.v113.pm9352871
State	Published - 1997
Externally published	Yes

ASJC Scopus subject areas

Hepatology
Gastroenterology

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10.1053/gast.1997.v113.pm9352871

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Dickson, R. C., Everhart, J. E., Lake, J. R., Wei, Y., Seaberg, E. C., Wiesner, R. H., Zetterman, R. K., Pruett, T. L., Ishitani, M. B., Hoofnagle, J. H., Detre, K. M., Demetris, A. J., Belle, S., Wei, Y., Lombardero, M., Seaberg, E., Lawlor, S., Eng, H., Fitzgerald, S., ... Shores, S. (1997). Transmission of hepatitis B by transplantation of livers from donors positive for antibody to hepatitis B core antigen. Gastroenterology, 113(5), 1668-1674. https://doi.org/10.1053/gast.1997.v113.pm9352871

Dickson, RC, Everhart, JE, Lake, JR, Wei, Y, Seaberg, EC, Wiesner, RH, Zetterman, RK, Pruett, TL, Ishitani, MB, Hoofnagle, JH, Detre, KM, Demetris, AJ, Belle, S, Wei, Y, Lombardero, M, Seaberg, E, Lawlor, S, Eng, H, Fitzgerald, S, Haber, J, Swanson, GL, Wiesner, R, Krom, R, Porayko, MK, Schwerman, L, Groettum, C, Zetterman, RK, Shaw B., J, Taylor, K, Ascher, N, Lake, J, Bremer-Kamp, C, Everhart, J & Shores, S 1997, 'Transmission of hepatitis B by transplantation of livers from donors positive for antibody to hepatitis B core antigen', Gastroenterology, vol. 113, no. 5, pp. 1668-1674. https://doi.org/10.1053/gast.1997.v113.pm9352871

@article{3d5a0cd7704145bebb179720fec9831c,

title = "Transmission of hepatitis B by transplantation of livers from donors positive for antibody to hepatitis B core antigen",

abstract = "Background and Aims: Organ donors are a potential source of transmissible disease after transplantation. The aim of this study was to evaluate the risk of acquiring hepatitis B among transplantation recipients of livers from donors without serum hepatitis B surface antigen (HBsAg) but with antibody to hepatitis B core antigen (anti-HBc). Methods: The transplantation experience of four centers between 1989 and 1994 was reviewed. Recipients of livers from 674 donors were considered informative for hepatitis B virus transmission. Results: Hepatitis B developed in 18 of 23 recipients of livers from anti-HBc-positive donors (78%) compared with only 3 of 651 recipients of anti-HBc-negative donor livers (0.5%) (P < 0.0001). HBsAg persisted in all recipients with donor-related hepatitis B. Liver histology showed chronic hepatitis of moderate severity in 2 of 13 recipients at 1 year and 5 of 8 recipients between 1.6 and 4.5 years from transplantation. Liver transplantation from an anti-HBc-positive donor was associated with decreased 4-year survival (adjusted mortality hazard ratio of 2.4; 95% confidence interval, 1.44.0). Conclusions: De novo posttransplantation hepatitis B infection occurs at a high rate in recipients of donors with anti-HBc. Transmission of hepatitis B through transplantation suggests that the virus may persist in the liver despite serological resolution of infection.",

author = "Dickson, {R. C.} and Everhart, {J. E.} and Lake, {J. R.} and Y. Wei and Seaberg, {E. C.} and Wiesner, {R. H.} and Zetterman, {R. K.} and Pruett, {T. L.} and Ishitani, {M. B.} and Hoofnagle, {J. H.} and Detre, {K. M.} and Demetris, {A. J.} and S. Belle and Y. Wei and M. Lombardero and E. Seaberg and S. Lawlor and H. Eng and S. Fitzgerald and J. Haber and Swanson, {G. L.} and R. Wiesner and R. Krom and Porayko, {M. K.} and L. Schwerman and C. Groettum and Zetterman, {R. K.} and {Shaw B.}, Jr and K. Taylor and N. Ascher and J. Lake and C. Bremer-Kamp and J. Everhart and S. Shores",

year = "1997",

doi = "10.1053/gast.1997.v113.pm9352871",

language = "English (US)",

volume = "113",

pages = "1668--1674",

journal = "Gastroenterology",

issn = "0016-5085",

publisher = "W.B. Saunders",

number = "5",

}

TY - JOUR

T1 - Transmission of hepatitis B by transplantation of livers from donors positive for antibody to hepatitis B core antigen

AU - Dickson, R. C.

AU - Everhart, J. E.

AU - Lake, J. R.

AU - Wei, Y.

AU - Seaberg, E. C.

AU - Wiesner, R. H.

AU - Zetterman, R. K.

AU - Pruett, T. L.

AU - Ishitani, M. B.

AU - Hoofnagle, J. H.

AU - Detre, K. M.

AU - Demetris, A. J.

AU - Belle, S.

AU - Wei, Y.

AU - Lombardero, M.

AU - Seaberg, E.

AU - Lawlor, S.

AU - Eng, H.

AU - Fitzgerald, S.

AU - Haber, J.

AU - Swanson, G. L.

AU - Wiesner, R.

AU - Krom, R.

AU - Porayko, M. K.

AU - Schwerman, L.

AU - Groettum, C.

AU - Zetterman, R. K.

AU - Shaw B., Jr

AU - Taylor, K.

AU - Ascher, N.

AU - Lake, J.

AU - Bremer-Kamp, C.

AU - Everhart, J.

AU - Shores, S.

PY - 1997

Y1 - 1997

N2 - Background and Aims: Organ donors are a potential source of transmissible disease after transplantation. The aim of this study was to evaluate the risk of acquiring hepatitis B among transplantation recipients of livers from donors without serum hepatitis B surface antigen (HBsAg) but with antibody to hepatitis B core antigen (anti-HBc). Methods: The transplantation experience of four centers between 1989 and 1994 was reviewed. Recipients of livers from 674 donors were considered informative for hepatitis B virus transmission. Results: Hepatitis B developed in 18 of 23 recipients of livers from anti-HBc-positive donors (78%) compared with only 3 of 651 recipients of anti-HBc-negative donor livers (0.5%) (P < 0.0001). HBsAg persisted in all recipients with donor-related hepatitis B. Liver histology showed chronic hepatitis of moderate severity in 2 of 13 recipients at 1 year and 5 of 8 recipients between 1.6 and 4.5 years from transplantation. Liver transplantation from an anti-HBc-positive donor was associated with decreased 4-year survival (adjusted mortality hazard ratio of 2.4; 95% confidence interval, 1.44.0). Conclusions: De novo posttransplantation hepatitis B infection occurs at a high rate in recipients of donors with anti-HBc. Transmission of hepatitis B through transplantation suggests that the virus may persist in the liver despite serological resolution of infection.

AB - Background and Aims: Organ donors are a potential source of transmissible disease after transplantation. The aim of this study was to evaluate the risk of acquiring hepatitis B among transplantation recipients of livers from donors without serum hepatitis B surface antigen (HBsAg) but with antibody to hepatitis B core antigen (anti-HBc). Methods: The transplantation experience of four centers between 1989 and 1994 was reviewed. Recipients of livers from 674 donors were considered informative for hepatitis B virus transmission. Results: Hepatitis B developed in 18 of 23 recipients of livers from anti-HBc-positive donors (78%) compared with only 3 of 651 recipients of anti-HBc-negative donor livers (0.5%) (P < 0.0001). HBsAg persisted in all recipients with donor-related hepatitis B. Liver histology showed chronic hepatitis of moderate severity in 2 of 13 recipients at 1 year and 5 of 8 recipients between 1.6 and 4.5 years from transplantation. Liver transplantation from an anti-HBc-positive donor was associated with decreased 4-year survival (adjusted mortality hazard ratio of 2.4; 95% confidence interval, 1.44.0). Conclusions: De novo posttransplantation hepatitis B infection occurs at a high rate in recipients of donors with anti-HBc. Transmission of hepatitis B through transplantation suggests that the virus may persist in the liver despite serological resolution of infection.

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U2 - 10.1053/gast.1997.v113.pm9352871

DO - 10.1053/gast.1997.v113.pm9352871

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AN - SCOPUS:0030830282

SN - 0016-5085

VL - 113

SP - 1668

EP - 1674

JO - Gastroenterology

JF - Gastroenterology

IS - 5

ER -

Transmission of hepatitis B by transplantation of livers from donors positive for antibody to hepatitis B core antigen

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