TY - JOUR
T1 - Transmission of drug-resistant tuberculosis among treated patients in Shanghai, China
AU - Li, Xia
AU - Zhang, Ying
AU - Shen, Xin
AU - Shen, Guomiao
AU - Gui, Xiaohong
AU - Sun, Bin
AU - Mei, Jian
AU - DeRiemer, Kathryn
AU - Small, Peter M.
AU - Gao, Qian
N1 - Funding Information:
Received 6 August 2006; accepted 8 November 2006; electronically published 1 February 2007. Potential conflicts of interest: none reported. Financial support: Key Project of Chinese National Programs for Fundamental Research and Development (973 program 2005CB523102 and 2002CB512804); Shanghai Key Medical Foundation (grant 05III029); Shanghai Municipal Science and Technology Commission (grants 05PJ14025 and 05DZ22320). Reprints or Correspondence: Dr. Qian Gao, Shanghai Medical College, Fudan University, 138 Yi Xue Yuan Rd., Shanghai, China, 200032 ([email protected]).
PY - 2007/3/15
Y1 - 2007/3/15
N2 - We sought to determine whether patients who had therapy failure with increasingly drug-resistant strains of tuberculosis had primary or acquired drug resistance, by genotyping the initial and subsequent drug-resistant clinical isolates of Mycobacterium tuberculosis collected from patients by the Shanghai Centers for Disease Control and Prevention over the course of a 5-year period. The vast majority of patients (27/32) had primary drug resistance, indicating transmission of a drug-resistant strain of M. tuberculosis. Only 16% (5/ 32) had acquired drug resistance because of a poor treatment regimen or nonadherence to an adequate regimen. Our findings highlight the urgency of increasing efforts to interrupt the transmission of drug-resistant tuberculosis in communities and facilities in Shanghai, China.
AB - We sought to determine whether patients who had therapy failure with increasingly drug-resistant strains of tuberculosis had primary or acquired drug resistance, by genotyping the initial and subsequent drug-resistant clinical isolates of Mycobacterium tuberculosis collected from patients by the Shanghai Centers for Disease Control and Prevention over the course of a 5-year period. The vast majority of patients (27/32) had primary drug resistance, indicating transmission of a drug-resistant strain of M. tuberculosis. Only 16% (5/ 32) had acquired drug resistance because of a poor treatment regimen or nonadherence to an adequate regimen. Our findings highlight the urgency of increasing efforts to interrupt the transmission of drug-resistant tuberculosis in communities and facilities in Shanghai, China.
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U2 - 10.1086/511985
DO - 10.1086/511985
M3 - Article
C2 - 17299717
AN - SCOPUS:33847670951
SN - 0022-1899
VL - 195
SP - 864
EP - 869
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 6
ER -