Transmission of drug-resistant tuberculosis among treated patients in Shanghai, China

Xia Li, Ying Zhang, Xin Shen, Guomiao Shen, Xiaohong Gui, Bin Sun, Jian Mei, Kathryn DeRiemer, Peter M. Small, Qian Gao

Research output: Contribution to journalArticlepeer-review

47 Scopus citations


We sought to determine whether patients who had therapy failure with increasingly drug-resistant strains of tuberculosis had primary or acquired drug resistance, by genotyping the initial and subsequent drug-resistant clinical isolates of Mycobacterium tuberculosis collected from patients by the Shanghai Centers for Disease Control and Prevention over the course of a 5-year period. The vast majority of patients (27/32) had primary drug resistance, indicating transmission of a drug-resistant strain of M. tuberculosis. Only 16% (5/ 32) had acquired drug resistance because of a poor treatment regimen or nonadherence to an adequate regimen. Our findings highlight the urgency of increasing efforts to interrupt the transmission of drug-resistant tuberculosis in communities and facilities in Shanghai, China.

Original languageEnglish (US)
Pages (from-to)864-869
Number of pages6
JournalJournal of Infectious Diseases
Issue number6
StatePublished - Mar 15 2007
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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