Abstract
We sought to determine whether patients who had therapy failure with increasingly drug-resistant strains of tuberculosis had primary or acquired drug resistance, by genotyping the initial and subsequent drug-resistant clinical isolates of Mycobacterium tuberculosis collected from patients by the Shanghai Centers for Disease Control and Prevention over the course of a 5-year period. The vast majority of patients (27/32) had primary drug resistance, indicating transmission of a drug-resistant strain of M. tuberculosis. Only 16% (5/ 32) had acquired drug resistance because of a poor treatment regimen or nonadherence to an adequate regimen. Our findings highlight the urgency of increasing efforts to interrupt the transmission of drug-resistant tuberculosis in communities and facilities in Shanghai, China.
Original language | English (US) |
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Pages (from-to) | 864-869 |
Number of pages | 6 |
Journal | Journal of Infectious Diseases |
Volume | 195 |
Issue number | 6 |
DOIs | |
State | Published - Mar 15 2007 |
Externally published | Yes |
ASJC Scopus subject areas
- Medicine(all)