@article{46bb2516d2ea443c8ee5a2d74bd1a21a,
title = "Transmission of antimicrobial-resistant staphylococcus aureus clonal complex 9 between pigs and humans, United States",
abstract = "Transmission of livestock-associated Staphylococcus aureus clonal complex 9 (LA-SA CC9) between pigs raised on industrial hog operations (IHO) and humans in the United States is poorly understood. We analyzed whole-genome sequences from 32 international S. aureus CC9 isolates and 49 LA-SA CC9 isolates from IHO pigs and humans who work on or live near IHOs in 10 pig-producing counties in North Carolina, USA. Bioinformatic analysis of sequence data from the 81 isolates demonstrated 3 major LA-SA CC9 clades. North Carolina isolates all fell within a single clade (C3). High-resolution phylogenetic analysis of C3 revealed 2 subclades of intermingled IHO pig and human isolates differing by 0–34 single-nucleotide polymorphisms. Our findings suggest that LA-SA CC9 from pigs and humans share a common source and provide evidence of transmission of antimicrobial-resistant LA-SA CC9 between IHO pigs and humans who work on or live near IHOs in North Carolina.",
author = "Randad, {Pranay R.} and Jesper Larsen and H{\"u}lya Kaya and Nora Pisanic and Carly Ordak and Price, {Lance B.} and Maliha Aziz and Nadimpalli, {Maya L.} and Sarah Rhodes and Stewart, {Jill R.} and Love, {Dave C.} and David Mohr and Davis, {Meghan F.} and Miller, {Lloyd S.} and Devon Hall and Carroll, {Karen C.} and Perl, {Trish M.} and Heaney, {Christopher D.}",
note = "Funding Information: This study was funded by the Sherrilyn and Ken Fisher Center for Environmental Infectious Diseases Discovery Program at the Johns Hopkins University, School of Medicine, Department of Medicine, Division of Infectious Diseases (award no. 018HEA2013); a gift from the GRACE Communications Foundation; the National Institute for Occupational Safety and Health (NIOSH) pilot award from the Johns Hopkins NIOSH Education and Research Center (grant no. T42OH008428); and NIOSH grant no. K01OH010193 and National Science Foundation (NSF) grant no. 1316318 as part of the joint NSF-NIH-USDA Ecology and Evolution of Infectious Diseases program. P.R.R. was supported by NIOSH (grant no. T42OH008428) and a gift from the GRACE Communications Foundation. J.L., L.B.P., and M.A. received funding support from the National Institute of Allergy and Infectious Diseases (NIAID; grant no. R01AI101371). C.D.H. received funding from NIOSH (grant no. K01OH010193). E.W. received funding from “Al” Thrasher Award 10287; a gift from the GRACE Communications Foundation; the National Institute of Environmental Health Sciences (grant no. R01ES026973); NIAID (grant nos. R21AI139784, R43AI141265, and R01AI130066); and the National Science Foundation (grant no. 1316318), as part of the joint NSF-NIH-USDA Ecology and Evolution of Infectious Diseases program. M.L.N. received funding support as part of a Royster Society fellowship and a US Environmental Protection Agency Science to Achieve Results fellowship. M.F.D. received funding support from NIH (grant no. K01OD019918). L.S.M received funding support from NIH (grant nos. R01AR069502 and R01AR073665). D.C.L. received funding support through a gift from the GRACE Communications Foundation. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: {\textcopyright} 2021 Centers for Disease Control and Prevention (CDC). All rights reserved.",
year = "2021",
month = mar,
doi = "10.3201/eid2703.191775",
language = "English (US)",
volume = "27",
pages = "740--748",
journal = "Emerging infectious diseases",
issn = "1080-6040",
publisher = "Centers for Disease Control and Prevention (CDC)",
number = "3",
}