Translocations involving c-myc and c-myc function

Linda M. Boxer, Chi V. Dang

Research output: Contribution to journalArticlepeer-review

351 Scopus citations


c-MYC is the prototype for oncogene activation by chromosomal translocation. In contrast to the tightly regulated expression of c-myc in normal cells, c-myc is frequently deregulated in human cancers. Herein, aspects of c-myc gene activation and the function of the c-Myc protein are reviewed. The c-myc gene produces an oncogenic transcription factor that affects diverse cellular processes involved in cell growth, cell proliferation, apoptosis and cellular metabolism. Complete removal of c-myc results in slowed cell growth and proliferation, suggesting that while c-myc is not required for cell proliferation, it acts as an integrator and accelerator of cellular metabolism and proliferation.

Original languageEnglish (US)
Pages (from-to)5595-5610
Number of pages16
Issue number40 REV. ISS. 4
StatePublished - Sep 10 2001


  • Apoptosis
  • c-myc
  • Gene expression
  • Lymphoma

ASJC Scopus subject areas

  • Molecular Biology
  • Cancer Research
  • Genetics


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