Translocations and Gene Fusions in Sinonasal Malignancies

Riley Larkin; Mario A. Hermsen; Nyall R. London

doi:10.1007/s11912-023-01364-x

Translocations and Gene Fusions in Sinonasal Malignancies

Riley Larkin, Mario A. Hermsen, Nyall R. London

School of Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

Purpose of Review: During the past few years there has been an expansion in our understanding of gene fusions and translocations involved in cancer of the sinonasal tract. Here we review the downstream biologic effects, clinical characteristics, and pathologic features of these tumors. The molecular consequences and neo-antigens resulting from these chromosomal aberrations are considered and targets for current and future clinical trials discussed. Recent Findings: Several new, clinically relevant, chromosomal aberrations have been discovered and evaluated to varying degrees in sinonasal tumors including DEK::AFF2, BRD4::NUT, ADCK4::NUMBL, and ETV6::NTRK3. Summary: Sinonasal malignancies demonstrate a diverse genetic landscape and varying clinical courses. Recent studies illustrate that gene fusions and translocations may play a role in carcinogenesis in certain sinonasal tumor subtypes and may be used to develop new biomarker-driven and patient-centered treatments.

Original language	English (US)
Pages (from-to)	269-278
Number of pages	10
Journal	Current oncology reports
Volume	25
Issue number	4
DOIs	https://doi.org/10.1007/s11912-023-01364-x
State	Published - Apr 2023

Keywords

Chimeric protein
Gene fusion
Neo-antigen
Sinonasal malignancies
Translocation

ASJC Scopus subject areas

Oncology

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10.1007/s11912-023-01364-x

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title = "Translocations and Gene Fusions in Sinonasal Malignancies",

abstract = "Purpose of Review: During the past few years there has been an expansion in our understanding of gene fusions and translocations involved in cancer of the sinonasal tract. Here we review the downstream biologic effects, clinical characteristics, and pathologic features of these tumors. The molecular consequences and neo-antigens resulting from these chromosomal aberrations are considered and targets for current and future clinical trials discussed. Recent Findings: Several new, clinically relevant, chromosomal aberrations have been discovered and evaluated to varying degrees in sinonasal tumors including DEK::AFF2, BRD4::NUT, ADCK4::NUMBL, and ETV6::NTRK3. Summary: Sinonasal malignancies demonstrate a diverse genetic landscape and varying clinical courses. Recent studies illustrate that gene fusions and translocations may play a role in carcinogenesis in certain sinonasal tumor subtypes and may be used to develop new biomarker-driven and patient-centered treatments.",

keywords = "Chimeric protein, Gene fusion, Neo-antigen, Sinonasal malignancies, Translocation",

author = "Riley Larkin and Hermsen, {Mario A.} and London, {Nyall R.}",

note = "Publisher Copyright: {\textcopyright} 2023, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.",

year = "2023",

month = apr,

doi = "10.1007/s11912-023-01364-x",

language = "English (US)",

volume = "25",

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journal = "Current oncology reports",

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T1 - Translocations and Gene Fusions in Sinonasal Malignancies

AU - Larkin, Riley

AU - Hermsen, Mario A.

AU - London, Nyall R.

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Y1 - 2023/4

N2 - Purpose of Review: During the past few years there has been an expansion in our understanding of gene fusions and translocations involved in cancer of the sinonasal tract. Here we review the downstream biologic effects, clinical characteristics, and pathologic features of these tumors. The molecular consequences and neo-antigens resulting from these chromosomal aberrations are considered and targets for current and future clinical trials discussed. Recent Findings: Several new, clinically relevant, chromosomal aberrations have been discovered and evaluated to varying degrees in sinonasal tumors including DEK::AFF2, BRD4::NUT, ADCK4::NUMBL, and ETV6::NTRK3. Summary: Sinonasal malignancies demonstrate a diverse genetic landscape and varying clinical courses. Recent studies illustrate that gene fusions and translocations may play a role in carcinogenesis in certain sinonasal tumor subtypes and may be used to develop new biomarker-driven and patient-centered treatments.

AB - Purpose of Review: During the past few years there has been an expansion in our understanding of gene fusions and translocations involved in cancer of the sinonasal tract. Here we review the downstream biologic effects, clinical characteristics, and pathologic features of these tumors. The molecular consequences and neo-antigens resulting from these chromosomal aberrations are considered and targets for current and future clinical trials discussed. Recent Findings: Several new, clinically relevant, chromosomal aberrations have been discovered and evaluated to varying degrees in sinonasal tumors including DEK::AFF2, BRD4::NUT, ADCK4::NUMBL, and ETV6::NTRK3. Summary: Sinonasal malignancies demonstrate a diverse genetic landscape and varying clinical courses. Recent studies illustrate that gene fusions and translocations may play a role in carcinogenesis in certain sinonasal tumor subtypes and may be used to develop new biomarker-driven and patient-centered treatments.

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KW - Neo-antigen

KW - Sinonasal malignancies

KW - Translocation

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Translocations and Gene Fusions in Sinonasal Malignancies

Abstract

Keywords

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