Translational strategies for cancer prevention in liver

Thomas W. Kensler, Geng Sun Qian, Jian Guo Chen, John D. Groopman

Research output: Contribution to journalReview articlepeer-review

173 Scopus citations

Abstract

Unlike many other types of human cancer, the aetiology of liver cancer is well understood. Infection with hepatitis viruses, coupled with dietary exposure to the fungal toxin aflatoxin, increases the risk of the disease. Although primary prevention, based on vaccination and avoiding exposure to these agents, is an appealing option, such strategies will require considerable investment of time and resources to be successful. In the developing world - where the burden of liver cancer is highest - immediate, practical and economical approaches are essential. So, targeted chemoprevention might be most appropriate for the present generation of individuals at risk.

Original languageEnglish (US)
Pages (from-to)321-329
Number of pages9
JournalNature Reviews Cancer
Volume3
Issue number5
DOIs
StatePublished - May 2003

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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