Transient Receptor Potential (TRP) Channels in Cochlear Function: Looking Beyond Mechanotransduction

Trinh Nguyen; Dwight E. Bergles

doi:10.1007/s10162-024-00954-1

Transient Receptor Potential (TRP) Channels in Cochlear Function: Looking Beyond Mechanotransduction

Trinh Nguyen, Dwight E. Bergles

School of Medicine

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

Transient receptor potential (TRP) channels play key roles in sensory biology as transducers of various stimuli. Although these ion channels are expressed in the cochlea, their functions remain poorly understood. Recent studies by Vélez-Ortega and colleagues indicate that their expression by non-sensory supporting cells helps limit damage from acoustic trauma.

Original language	English (US)
Journal	JARO - Journal of the Association for Research in Otolaryngology
DOIs	https://doi.org/10.1007/s10162-024-00954-1
State	Accepted/In press - 2024

Keywords

Cochlear supporting cells
Noise-induced damage
Oxidative stress sensing
TRPA1

ASJC Scopus subject areas

Otorhinolaryngology
Sensory Systems

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10.1007/s10162-024-00954-1

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title = "Transient Receptor Potential (TRP) Channels in Cochlear Function: Looking Beyond Mechanotransduction",

abstract = "Transient receptor potential (TRP) channels play key roles in sensory biology as transducers of various stimuli. Although these ion channels are expressed in the cochlea, their functions remain poorly understood. Recent studies by V{\'e}lez-Ortega and colleagues indicate that their expression by non-sensory supporting cells helps limit damage from acoustic trauma.",

keywords = "Cochlear supporting cells, Noise-induced damage, Oxidative stress sensing, TRPA1",

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AU - Bergles, Dwight E.

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AB - Transient receptor potential (TRP) channels play key roles in sensory biology as transducers of various stimuli. Although these ion channels are expressed in the cochlea, their functions remain poorly understood. Recent studies by Vélez-Ortega and colleagues indicate that their expression by non-sensory supporting cells helps limit damage from acoustic trauma.

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KW - Noise-induced damage

KW - Oxidative stress sensing

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Transient Receptor Potential (TRP) Channels in Cochlear Function: Looking Beyond Mechanotransduction

Abstract

Keywords

ASJC Scopus subject areas

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