Transglutaminases: Effector molecules in physiologic cell death

L. Nagy, V. Thomazy, P. J.A. Davies

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations


TRANSGLUTAMINASES are protein cross-linking enzymes that catalyze the formation of large protein aggregates. The intracellular members of the family, keratinocyte transglutaminase (type I) and tissue transglutaminase (type II), appear to be involved in the apoptotic program. The keratinocyte- specific enzyme is restricted to the epidermis and responsible for the cornification of keratinocytes by forming the cornified envelopes. The tissue enzyme can be found in other organs and participates in the formation of apoptotic bodies by cross-linking substrate proteins.

Original languageEnglish (US)
Pages (from-to)136-140
Number of pages5
JournalCancer Bulletin
Issue number2
StatePublished - Jan 1 1994
Externally publishedYes

ASJC Scopus subject areas

  • Cancer Research


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