Transforming growth factor beta stimulates phosphoinositol metabolism and translocation of protein kinase C in cultured astrocytes

Patricia L. Robertson; Jasna Markovac; Subhash C. Datta; Gary W. Goldstein

doi:10.1016/0304-3940(88)90021-3

Transforming growth factor beta stimulates phosphoinositol metabolism and translocation of protein kinase C in cultured astrocytes

Patricia L. Robertson, Jasna Markovac, Subhash C. Datta, Gary W. Goldstein

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Transforming growth factor beta (TGF-β) is a regulatory peptide found in many normal and neoplastic tissues, including brain, with a diverse range of cellular effects. The transmembrane biochemical signals by which TGF-β exerts these effects and the second messenger systems that may amplify them are unknown. We investigated the effects of TGF-β upon membrane phosphoinositol metabolism and protein kinase C activity in cultured astrocytes. We found that exposure of astrocyte enriched cultures to TGF-β resulted in the stimulation of phosphoinositol lipid turnover to inositol phosphates and in the apparent redistribution of protein kinase C from cytosol to membrane.

Original language	English (US)
Pages (from-to)	107-113
Number of pages	7
Journal	Neuroscience Letters
Volume	93
Issue number	1
DOIs	https://doi.org/10.1016/0304-3940(88)90021-3
State	Published - Oct 31 1988
Externally published	Yes

Keywords

Astrocyte
Phosphoinositol metabolism
Protein kinase C
Transforming growth factor beta

ASJC Scopus subject areas

Neuroscience(all)

Access to Document

10.1016/0304-3940(88)90021-3

Cite this

@article{f2c6ba6d5c3e43e4b186bb87fdd7d684,

title = "Transforming growth factor beta stimulates phosphoinositol metabolism and translocation of protein kinase C in cultured astrocytes",

abstract = "Transforming growth factor beta (TGF-β) is a regulatory peptide found in many normal and neoplastic tissues, including brain, with a diverse range of cellular effects. The transmembrane biochemical signals by which TGF-β exerts these effects and the second messenger systems that may amplify them are unknown. We investigated the effects of TGF-β upon membrane phosphoinositol metabolism and protein kinase C activity in cultured astrocytes. We found that exposure of astrocyte enriched cultures to TGF-β resulted in the stimulation of phosphoinositol lipid turnover to inositol phosphates and in the apparent redistribution of protein kinase C from cytosol to membrane.",

keywords = "Astrocyte, Phosphoinositol metabolism, Protein kinase C, Transforming growth factor beta",

author = "Robertson, {Patricia L.} and Jasna Markovac and Datta, {Subhash C.} and Goldstein, {Gary W.}",

note = "Funding Information: This work was supported by Grants EY03772 and ES02380 from the National Institutes of Health.",

year = "1988",

month = oct,

day = "31",

doi = "10.1016/0304-3940(88)90021-3",

language = "English (US)",

volume = "93",

pages = "107--113",

journal = "Neuroscience Letters",

issn = "0304-3940",

publisher = "Elsevier Ireland Ltd",

number = "1",

}

TY - JOUR

T1 - Transforming growth factor beta stimulates phosphoinositol metabolism and translocation of protein kinase C in cultured astrocytes

AU - Robertson, Patricia L.

AU - Markovac, Jasna

AU - Datta, Subhash C.

AU - Goldstein, Gary W.

N1 - Funding Information: This work was supported by Grants EY03772 and ES02380 from the National Institutes of Health.

PY - 1988/10/31

Y1 - 1988/10/31

N2 - Transforming growth factor beta (TGF-β) is a regulatory peptide found in many normal and neoplastic tissues, including brain, with a diverse range of cellular effects. The transmembrane biochemical signals by which TGF-β exerts these effects and the second messenger systems that may amplify them are unknown. We investigated the effects of TGF-β upon membrane phosphoinositol metabolism and protein kinase C activity in cultured astrocytes. We found that exposure of astrocyte enriched cultures to TGF-β resulted in the stimulation of phosphoinositol lipid turnover to inositol phosphates and in the apparent redistribution of protein kinase C from cytosol to membrane.

AB - Transforming growth factor beta (TGF-β) is a regulatory peptide found in many normal and neoplastic tissues, including brain, with a diverse range of cellular effects. The transmembrane biochemical signals by which TGF-β exerts these effects and the second messenger systems that may amplify them are unknown. We investigated the effects of TGF-β upon membrane phosphoinositol metabolism and protein kinase C activity in cultured astrocytes. We found that exposure of astrocyte enriched cultures to TGF-β resulted in the stimulation of phosphoinositol lipid turnover to inositol phosphates and in the apparent redistribution of protein kinase C from cytosol to membrane.

KW - Astrocyte

KW - Phosphoinositol metabolism

KW - Protein kinase C

KW - Transforming growth factor beta

UR - http://www.scopus.com/inward/record.url?scp=0023756074&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023756074&partnerID=8YFLogxK

U2 - 10.1016/0304-3940(88)90021-3

DO - 10.1016/0304-3940(88)90021-3

M3 - Article

C2 - 3211365

AN - SCOPUS:0023756074

SN - 0304-3940

VL - 93

SP - 107

EP - 113

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 1

ER -

Transforming growth factor beta stimulates phosphoinositol metabolism and translocation of protein kinase C in cultured astrocytes

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this